Galectin-3 is a key hepatoprotective molecule against the deleterious effect of cisplatin

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorSantos, Diego D.-
Autor(es): dc.creatorSasso, Gisela R.S.-
Autor(es): dc.creatorBelote, Nycole M.-
Autor(es): dc.creatorda Silva, Rafael André-
Autor(es): dc.creatorLice, Izabella-
Autor(es): dc.creatorCorreia-Silva, Rebeca D.-
Autor(es): dc.creatorBorges, Fernanda T.-
Autor(es): dc.creatorCarbonel, Adriana A.F.-
Autor(es): dc.creatorGil, Cristiane D.-
Data de aceite: dc.date.accessioned2025-08-21T18:43:17Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:17Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2023.121505-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246849-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246849-
Descrição: dc.descriptionAims: Evaluate the role of galectin-3 in the liver using an acute model of cisplatin-induced toxicity. Material and methods: Modified citrus pectin (MCP) treatment was used to inhibit galectin-3. Rats were distributed into four groups: SHAM, CIS, MCP and MCP + CIS. On days 1–7, animals were treated by oral gavage with 100 mg/kg/day of MCP (MCP and MCP + CIS groups). On days 8, 9 and 10, animals received intraperitoneal injection of 10 mg/kg/day of cisplatin (CIS and MCP + CIS groups) or saline (SHAM and MCP groups). Key findings: Cisplatin administration caused a marked increase in hepatic leukocyte influx and liver degeneration, and promoted reactive oxygen species production and STAT3 activation in hepatocytes. Plasma levels of cytokines (IL-6, IL-10), and hepatic toxicity biomarkers (hepatic arginase 1, α-glutathione S-transferase, sorbitol dehydrogenase) were also elevated. Decreased galectin-3 levels in the livers of animals in the MCP + CIS group were also associated with increased hepatic levels of malondialdehyde and mitochondrial respiratory complex I. Animals in the MCP + CIS group also exhibited increased plasma levels of IL-1β, TNF-α, and aspartate transaminase 1. Furthermore, MCP therapy efficiently antagonized hepatic galectin-9 in liver, but not galectin-1, the latter of which was increased. Significance: Reduction of the endogenous levels of galectin-3 in hepatocytes favors the process of cell death and increases oxidative stress in the acute model of cisplatin-induced toxicity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBiosciences Graduate Program Institute of Biosciences Letters and Exact Sciences Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionStructural and Functional Biology Graduate Program Universidade Federal de São Paulo (UNIFESP), SP-
Descrição: dc.descriptionDepartment of Medicine Nephrology Division Universidade Federal de São Paulo (UNIFESP), SP-
Descrição: dc.descriptionBiosciences Graduate Program Institute of Biosciences Letters and Exact Sciences Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 20/03565-2-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHepatotoxicity-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectLipid peroxidation-
Palavras-chave: dc.subjectMitochondria-
Palavras-chave: dc.subjectModified citrus pectin-
Palavras-chave: dc.subjectReactive oxygen species-
Título: dc.titleGalectin-3 is a key hepatoprotective molecule against the deleterious effect of cisplatin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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