Evaluation of the Efficacy of Lactobacillus acidophilus in the Treatment of Cyclophosphamide-induced Hemorrhagic Cystitis in Wistar Rats

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Autor(es): dc.contributorFederal University of Grande Dourados (UFGD)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity Center of Grande Dourados (UNIGRAN)-
Autor(es): dc.creatorMinhos, Liandra Ferreira-
Autor(es): dc.creatorde Lima Gehlen, Ana Cláudia da Silva-
Autor(es): dc.creatorJúnior, Felipe Francisco Bittencourt-
Autor(es): dc.creatorDos Santos, Ariany Carvalho-
Autor(es): dc.creatorSouza, Roosevelt Isaias Carvalho-
Autor(es): dc.creatorde Barros, Márcio Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T16:48:41Z-
Data de disponibilização: dc.date.available2025-08-21T16:48:41Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1389201023666220429121953-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246806-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246806-
Descrição: dc.descriptionBackground: Hemorrhagic cystitis is an inflammatory complication that can be caused by the administration of cyclophosphamide, which is widely used as an antineoplastic agent. In the search for new therapeutic alternatives, probiotics can suppress the inflammatory process and, there-fore, can be used to prevent this disease. Objective: Thus, this study aimed to evaluate the effects of using Lactobacillus acidophilus NCFM in the treatment of cyclophosphamide-induced hemorrhagic cystitis in Wistar rats. Methods: Lactobacillus acidophilus NCFM (2x108 CFU) was used in the treatment of cyclophos-phamide-induced hemorrhagic cystitis (200 mg/kg, intraperitoneal) in 77 female Wistar rats. Rats were distributed into experimental groups (n = 9): control group (GC), zero control group (GCZ), inflammation group (GI), 24-hour acute treatment groups: 24-hour lactobacilli treatment group (GL24H) and mesna group (GM), and 30-day chronic treatment groups: lactobacilli treatment group (GTL) and mesna+lactobacilli group (GM+L). After treatment, animals were euthanized and biological materials were collected for blood count, biochemical analyses, examination of abnormal sedi-ment elements (EAS), and histopathological analysis. Results: GI results showed development of edema, macroscopic alterations, and signs of bleeding in the bladder; in addition, lesions in the urothelium and hemorrhage were also found. GL24H and GM presented intact urothelium, without inflammatory reaction and hematological or biochemical urine alterations. Conclusion: Therefore, this study demonstrated that L. acidophilus presented uroprotective effect against the action of cyclophosphamide in both the short and long term.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Health Sciences Faculty of Health Sciences Federal University of Grande Dourados (UFGD)-
Descrição: dc.descriptionDepartment of structural and functional biology Faculty of General and Applied Biology “Julio de Mesquita Filho” São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinical Biochemistry Faculty of Biomedicine University Center of Grande Dourados (UNIGRAN)-
Descrição: dc.descriptionDepartment of structural and functional biology Faculty of General and Applied Biology “Julio de Mesquita Filho” São Paulo State University (UNESP)-
Formato: dc.format438-449-
Idioma: dc.languageen-
Relação: dc.relationCurrent Pharmaceutical Biotechnology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbladder inflammation-
Palavras-chave: dc.subjectcyclophosphamide-
Palavras-chave: dc.subjectHemorrhagic cystitis-
Palavras-chave: dc.subjectLactobacillus spp-
Palavras-chave: dc.subjectprobiotics-
Palavras-chave: dc.subjectwistar rats-
Título: dc.titleEvaluation of the Efficacy of Lactobacillus acidophilus in the Treatment of Cyclophosphamide-induced Hemorrhagic Cystitis in Wistar Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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