Platelets and endothelial dysfunction in gestational diabetes mellitus

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Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.contributorUniversity Medical Centre Groningen (UMCG)-
Autor(es): dc.contributorUniversidad de Antofagasta-
Autor(es): dc.contributorUniversidad del Bío-Bío-
Autor(es): dc.contributorUniversity Medical Center Groningen (UMCG)-
Autor(es): dc.contributorSocieté des Produits de Nestlé-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.creatorValero, Paola-
Autor(es): dc.creatorCornejo, Marcelo-
Autor(es): dc.creatorFuentes, Gonzalo-
Autor(es): dc.creatorWehinger, Sergio-
Autor(es): dc.creatorToledo, Fernando-
Autor(es): dc.creatorvan der Beek, Eline M.-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorMoore-Carrasco, Rodrigo-
Data de aceite: dc.date.accessioned2025-08-21T23:08:38Z-
Data de disponibilização: dc.date.available2025-08-21T23:08:38Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/apha.13940-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246772-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246772-
Descrição: dc.descriptionThe prevalence of gestational diabetes mellitus (GDM) has increased in recent years, along with the higher prevalence of obesity in women of reproductive age. GDM is a pathology associated with vascular dysfunction in the fetoplacental unit. GDM-associated endothelial dysfunction alters the transfer of nutrients to the foetus affecting newborns and pregnant women. Various mechanisms for this vascular dysfunction have been proposed, of which the most studied are metabolic alterations of the vascular endothelium. However, different cell types are involved in GDM-associated endothelial dysfunction, including platelets. Platelets are small, enucleated cell fragments that actively take part in blood haemostasis and thrombus formation. Thus, they play crucial roles in pathologies coursing with endothelial dysfunction, such as atherosclerosis, cardiovascular diseases, and diabetes mellitus. Nevertheless, platelet function in GDM is understudied. Several reports show a potential relationship between platelet volume and mass with GDM; however, platelet roles and signaling mechanisms in GDM-associated endothelial dysfunction are unclear. This review summarizes the reported findings and proposes a link among altered amount, volume, mass, reactivity, and function of platelets and placenta development, resulting in fetoplacental vascular dysfunction in GDM.-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Division of Obstetrics and Gynaecology Department of Obstetrics Faculty of Medicine School of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Talca-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Centre Groningen (UMCG)-
Descrição: dc.descriptionBiomedical Department Faculty of Health Sciences Universidad de Antofagasta-
Descrição: dc.descriptionDepartment of Basic Sciences Faculty of Sciences Universidad del Bío-Bío-
Descrição: dc.descriptionDepartment of Pediatrics University of Groningen University Medical Center Groningen (UMCG)-
Descrição: dc.descriptionNestlé Institute for Health Sciences Nestlé Research Societé des Produits de Nestlé-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionFAPESP: 2016 ∕ 01743-5-
Idioma: dc.languageen-
Relação: dc.relationActa Physiologica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdiabetes mellitus-
Palavras-chave: dc.subjectendothelium-
Palavras-chave: dc.subjectgestational diabetes-
Palavras-chave: dc.subjectplatelet-
Palavras-chave: dc.subjectpregnancy-
Título: dc.titlePlatelets and endothelial dysfunction in gestational diabetes mellitus-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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