Molecular phenotypes of bovine blastocyst derived from in vitro-matured oocyte supplemented with PAPP-A

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorUniversity of Western São Paulo-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.creatorDellaqua, Thaisy Tino-
Autor(es): dc.creatorFranchi, Fernanda Fagali-
Autor(es): dc.creatordos Santos, Priscila Helena-
Autor(es): dc.creatorGiroto, Alan Brunholi-
Autor(es): dc.creatorNunes, Sarah Gomes-
Autor(es): dc.creatorde Lima, Victor Augusto Vieira-
Autor(es): dc.creatorGuilherme, Vitória Bertogna-
Autor(es): dc.creatorFontes, Patrícia Kubo-
Autor(es): dc.creatorSudano, Mateus José-
Autor(es): dc.creatorde Souza Castilho, Anthony César-
Data de aceite: dc.date.accessioned2025-08-21T18:16:41Z-
Data de disponibilização: dc.date.available2025-08-21T18:16:41Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11259-023-10072-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246662-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246662-
Descrição: dc.descriptionInsulin-like growth factor-1 (IGF-1) regulates cellular lipid content, whereas pregnancy-associated plasma protein-A (PAPP-A) increases IGF-1 bioavailability. Using in vitro-matured cumulus-oocyte complexes, we aimed to evaluate the impact of PAPP-A on the blastocyst lipid content, embryo cryotolerance and embryonic transcriptional profile. We determined that PAPP-A did not affect the lipid content of oocytes, blastocysts, or blastocyst yield (P > 0.05). However, PAPP-A modulated the embryo transcriptional profiles by downregulating PPARGC1A and AKR1B1, which are related to lipid metabolism; CASP9, a pro-apoptotic gene; and IFN-τ, a marker of embryo quality (P < 0.05). Furthermore, the use of PAPP-A improved blastocyst re-expansion in the first 3 h of culture after vitrification (P < 0.05). Although PAPP-A did not affect the blastocyst lipid content or embryo production, we suggest that embryonic transcriptional modulation could contribute to maintain the balance in embryo lipid metabolism. Furthermore, PAPP-A’s approach seems to control key intracellular pathways that improve post-cryopreservation development of blastocysts.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionReproductive and Developmental Biology Laboratory Department of Veterinary Medicine and Animal Science University of Milan-
Descrição: dc.descriptionUniversity of Western São Paulo, SP-
Descrição: dc.descriptionDepartment of Biology São Paulo State University, SP-
Descrição: dc.descriptionCenter of Natural and Human Sciences Federal University of ABC, SP-
Descrição: dc.descriptionCenter of Biological and Health Sciences Federal University of São Carlos, SP-
Descrição: dc.descriptionUniversity of Western São Paulo (UNOESTE), Campus II, Rodovia Raposo Tavares, km 572, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biology São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Research Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBlastocyst-
Palavras-chave: dc.subjectCattle-
Palavras-chave: dc.subjectGene expression-
Palavras-chave: dc.subjectLipid content-
Palavras-chave: dc.subjectOocyte in vitro maturation-
Palavras-chave: dc.subjectPAPP-A-
Título: dc.titleMolecular phenotypes of bovine blastocyst derived from in vitro-matured oocyte supplemented with PAPP-A-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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