Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRuiz, Uriel Enrique Aquino-
Autor(es): dc.creatorSantos, Igor Andrade-
Autor(es): dc.creatorGrosche, Victória Riquena-
Autor(es): dc.creatorFernandes, Rafaela Sachetto-
Autor(es): dc.creatorde Godoy, Andre Schutzer-
Autor(es): dc.creatorTorres, Jhoan David Aguillón-
Autor(es): dc.creatorFreire, Marjorie Caroline Liberato Cavalcanti-
Autor(es): dc.creatorMesquita, Nathalya Cristina de Moraes Roso-
Autor(es): dc.creatorGuevara-Vega, Marco-
Autor(es): dc.creatorNicolau-Junior, Nilson-
Autor(es): dc.creatorSabino-Silva, Robinson-
Autor(es): dc.creatorMineo, Tiago Wilson Patriarca-
Autor(es): dc.creatorOliva, Glaucius-
Autor(es): dc.creatorJardim, Ana Carolina Gomes-
Data de aceite: dc.date.accessioned2025-08-21T21:42:55Z-
Data de disponibilização: dc.date.available2025-08-21T21:42:55Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.virusres.2022.199029-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246619-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246619-
Descrição: dc.descriptionThe Chikungunya virus (CHIKV) causes Chikungunya fever, a disease characterized by symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved against CHIKV, emphasizing the need to develop novel therapies. The imidazonaphthyridine compound (RO8191), an interferon-α (IFN-α) agonist, was reported as a potent inhibitor of HCV. Here RO8191 was investigated for its potential to inhibit CHIKV replication in vitro. RO8191 inhibited CHIKV infection in BHK-21 and Vero-E6 cells with a selectivity index (SI) of 12.3 and 37.3, respectively. Additionally, RO8191 was capable to protect cells against CHIKV infection, inhibit entry by virucidal activity, and strongly impair post-entry steps of viral replication. An effect of RO8191 on CHIKV replication was demonstrated in BHK-21 through type-1 IFN production mechanism and in Vero-E6 cells which has a defective type-1 IFN production, also suggesting a type-1 IFN independent mode of action. Molecular docking calculations demonstrated interactions of RO8191 with the CHIKV E proteins, corroborated by the ATR-FTIR assay, and with non-structural proteins, supported by the CHIKV-subgenomic replicon cells assay.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biomedical Science Federal University of Uberlândia (UFU), MG-
Descrição: dc.descriptionSao Carlos Institute of Physics University of Sao Paulo (USP), SP-
Descrição: dc.descriptionInstitute of Biotechnology Federal University of Uberlândia (UFU), MG-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationVirus Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiviral activity-
Palavras-chave: dc.subjectChikungunya Fever-
Palavras-chave: dc.subjectChikungunya virus-
Palavras-chave: dc.subjectImidazonaphthyridine-
Palavras-chave: dc.subjectNeglected tropical diseases-
Palavras-chave: dc.subjectType-1 IFN independent activity-
Título: dc.titleImidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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