FoxO3 and oxidative stress: a multifaceted role in cellular adaptation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorBernardo, Victoria Simões-
Autor(es): dc.creatorTorres, Flaviene Felix-
Autor(es): dc.creatorda Silva, Danilo Grünig Humberto-
Data de aceite: dc.date.accessioned2025-08-21T21:45:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:45:18Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00109-022-02281-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246593-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246593-
Descrição: dc.descriptionOxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of physiological and pathological processes by regulating multiple gene regulatory networks involved in the modulation of numerous aspects of cellular metabolism, including fuel metabolism, cell death, and stress resistance. This review will also focus on regulatory mechanisms of FoxO3 expression and activity, such as crucial post-translational modifications and non-coding RNAs. Moreover, this work discusses and evidences some pathways to how this transcription factor and reactive oxygen species regulate each other, which may lead to the pathogenesis of various types of diseases. Therefore, in addition to being a promising therapeutic target, the FoxO3-regulated signaling pathways can also be used as reliable diagnostic and prognostic biomarkers and indicators for drug responsiveness.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biology Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso Do Sul (CPTL/UFMS), Campus de Três Lagoas, Avenida Ranulpho Marques Leal, 3484, Mato Grosso Do Sul, Distrito Industrial–Post code-
Descrição: dc.descriptionDepartment of Biology Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCNPq: 406700/2021-4-
Descrição: dc.descriptionCAPES: Finance Code 001-
Formato: dc.format83-99-
Idioma: dc.languageen-
Relação: dc.relationJournal of Molecular Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectPathological processes-
Palavras-chave: dc.subjectReactive oxygen species-
Palavras-chave: dc.subjectRegulatory networks-
Palavras-chave: dc.subjectTherapeutic target-
Título: dc.titleFoxO3 and oxidative stress: a multifaceted role in cellular adaptation-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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