Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorFundação Universidade Regional de Blumenau (FURB)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorTorres, Flaviene Felix-
Autor(es): dc.creatorBernardo, Victoria Simões-
Autor(es): dc.creatorde Paula, Carla Peres-
Autor(es): dc.creatorda Silva, João Pedro Maia de Oliveira-
Autor(es): dc.creatorde Almeida, Eduardo Alves-
Autor(es): dc.creatorda Cunha, Anderson Ferreira-
Autor(es): dc.creatorda Silva, Danilo Grünig Humberto-
Data de aceite: dc.date.accessioned2025-08-21T20:07:51Z-
Data de disponibilização: dc.date.available2025-08-21T20:07:51Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/genes13122337-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246507-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246507-
Descrição: dc.descriptionMelatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL on the redox signaling pathways PI3K/AKT/FoxO3 and Keap1/Nrf2/ARE in K562 erythroleukemic cells subjected to OS induction. For this, the viability, and transcript levels of genes involved in redox adaptation were evaluated in K562 cells in different periods of erythroid differentiation: under OS induction by hydrogen peroxide (100 µM H2O2); treated with 1 nM (C1) and 1 mM (C2) MEL; and associated or not with stress induction. We observed a restoration of physiological levels of Nrf2 in both MEL concentrations under OS. The C1 was related to enhanced expression of antioxidant and proteasome genes through the Nrf2-ARE pathway, while C2 to the induction of FOXO3 expression, suggesting an involvement with apoptotic pathway, according to BIM transcript levels. The effects of MEL administration in these cells showed a period and dose-dependent pattern against induced-OS, with direct and indirect actions through different pathways of cellular adaptation, reinforcing the importance of this indolamine in the regulation of cellular homeostasis, being a promising therapeutic alternative for diseases that present an exacerbated OS.-
Descrição: dc.descriptionDepartment of Biology Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Genetics and Evolution Universidade Federal de São Carlos (UFSCar), SP-
Descrição: dc.descriptionDepartment of Natural Sciences Fundação Universidade Regional de Blumenau (FURB), SC-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso do Sul (CPTL/UFMS), Campus de Três Lagoas, MS-
Descrição: dc.descriptionDepartment of Biology Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationGenes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidant therapy-
Palavras-chave: dc.subjectFoxO3-
Palavras-chave: dc.subjectN-[2-(5-methoxy-1H-indol-3-yl)ethyl]-
Palavras-chave: dc.subjectNrf2-
Título: dc.titleInfluence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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