Chemosensory Dysfunction 3-Months After COVID-19, Medications and Factors Associated with Complete Recovery

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Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorPontifical Catholic University of Paraná-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Pennsylvania-
Autor(es): dc.creatorFornazieri, Marco Aurélio-
Autor(es): dc.creatorSilva, José Lucas Barbosa da-
Autor(es): dc.creatorGameiro, Juliana Gutschow-
Autor(es): dc.creatorScussiato, Henrique Ochoa-
Autor(es): dc.creatorRamos, Rafael Antônio Matias Ribeiro-
Autor(es): dc.creatorCunha, Bruno Machado-
Autor(es): dc.creatorFigueiredo, Alan Felipe-
Autor(es): dc.creatorTakahashi, Eduardo Hideki-
Autor(es): dc.creatorMarin, Gabrielli Algazal-
Autor(es): dc.creatorCaetano, Igor Ruan de Araújo-
Autor(es): dc.creatorMeli, Tainara Kawane-
Autor(es): dc.creatorHiguchi, Diego Issamu-
Autor(es): dc.creatorSantos, Rafael Rodrigues Pinheiro dos-
Autor(es): dc.creatorRampazzo, Ana Carla Mondek-
Autor(es): dc.creatorPinna, Fábio de Rezende-
Autor(es): dc.creatorVoegels, Richard Louis-
Autor(es): dc.creatorDoty, Richard L.-
Data de aceite: dc.date.accessioned2025-08-21T19:29:50Z-
Data de disponibilização: dc.date.available2025-08-21T19:29:50Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/00034894221138485-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246500-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246500-
Descrição: dc.descriptionObjectives: To examine the longitudinal prevalence and recovery of olfactory, gustatory, and oral chemesthetic deficits in a sizable cohort of SARS-CoV-2 infected persons using quantitative testing. To determine whether demographic and clinical factors, mainly the medications used after the COVID-19 diagnosis, influence the test measures. Methods: Prospective cohort in a hospital with primary, secondary, tertiary, and quaternary care. Patients with confirmed COVID-19 were tested during the acute infection phase (within 15 days of initial symptom, n = 187) and one (n = 113) and 3 months later (n = 73). The University of Pennsylvania Smell Identification Test, the Global Gustatory Test, and a novel test for chemesthesis were administered at all visits. Results: During the acute phase, 93% were anosmic or microsmic and 29.4% were hypogeusic. No one was ageusic. A deficit in oral chemesthesis was present in 13.4%. By 3 months, taste and chemesthesis had largely recovered, however, some degree of olfactory dysfunction remained in 54.8%. Remarkably, patients who had been treated with anticoagulants tended to have more olfactory improvement. Recovery was greater in men than in women, but was unrelated to disease severity, smoking behavior, or the use of various medications prior to, or during, COVID-19 infection. Conclusions: When using quantitative testing, olfactory disturbances were found in nearly all SARS-CoV-2 infected patients during the acute infection phase. Taste or chemesthetic deficits were low. Olfactory impairment persisted to some degree in over half of the patients at the 3-month follow-up evaluation, being more common in women and less common in those who had been treated earlier with anticoagulants. Level of Evidence: 3-
Descrição: dc.descriptionLondrina State University, Paraná-
Descrição: dc.descriptionPontifical Catholic University of Paraná-
Descrição: dc.descriptionUniversity of São Paulo, State of São Paulo-
Descrição: dc.descriptionSmell and Taste Center Department of Otorhinolaryngology Head and Neck Surgery Perelman School of Medicine University of Pennsylvania-
Idioma: dc.languageen-
Relação: dc.relationAnnals of Otology, Rhinology and Laryngology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectdiagnostic tests-
Palavras-chave: dc.subjectolfaction disorders-
Palavras-chave: dc.subjectolfactory perception-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectsex-
Palavras-chave: dc.subjectsmell-
Palavras-chave: dc.subjecttaste-
Título: dc.titleChemosensory Dysfunction 3-Months After COVID-19, Medications and Factors Associated with Complete Recovery-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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