Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Franca (UNIFRAN)-
Autor(es): dc.creatorSilva, Nagela Bernadelli Sousa-
Autor(es): dc.creatorde Souza, Jonathan Henrique-
Autor(es): dc.creatorSantiago, Mariana Brentini-
Autor(es): dc.creatorda Silva Aguiar, Jhennyfer Rodrigues-
Autor(es): dc.creatorMartins, Daniel Oliveira Silva-
Autor(es): dc.creatorda Silva, Rafael Alves-
Autor(es): dc.creatorde Andrade Santos, Igor-
Autor(es): dc.creatorAldana-Mejía, Jennyfer A.-
Autor(es): dc.creatorJardim, Ana Carolina Gomes-
Autor(es): dc.creatordos Santos Pedroso, Reginaldo-
Autor(es): dc.creatorAmbrósio, Sergio Ricardo-
Autor(es): dc.creatorVeneziani, Rodrigo Cássio Sola-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorPires, Regina Helena-
Autor(es): dc.creatorMartins, Carlos Henrique Gomes-
Data de aceite: dc.date.accessioned2025-08-21T21:07:34Z-
Data de disponibilização: dc.date.available2025-08-21T21:07:34Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-022-24776-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246432-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246432-
Descrição: dc.descriptionBacterial and viral infections are serious public health issue. Therefore, this study aimed to evaluate the antibacterial, antibiofilm and antiviral potential of the Brazilian Red Propolis (BRP) crude hydroalcoholic extract, fractions, and isolated compounds, as well as their in vivo toxicity. The antibacterial activity was evaluated by determining the Minimum Inhibitory Concentration and the antibiofilm activity by determining the Minimum Inhibitory Concentration of Biofilm (MICB50). The viable bacteria count (Log10 UFC/mL) was also obtained. The antiviral assays were performed by infecting BHK-21 cells with Chikungunya (CHIKV) nanoluc. The toxicity of the BRP was evaluated in the Caenorhabditis elegans animal model. The MIC values for the crude hydroalcoholic extract sample ranged from 3.12 to 100 μg/mL, while fractions and isolated compounds the MIC values ranged from 1.56 to 400 μg/mL.The BRP crude hydroalcoholic extract, oblongifolin B, and gutiferone E presented MICB50 values ranging from 1.56 to 100 μg/mL against monospecies and multispecies biofilms. Neovestitol and vestitol inhibited CHIKV infection by 93.5 and 96.7%, respectively. The tests to evaluate toxicity in C. elegans demonstrated that the BRP was not toxic below the concentrations 750 μg/mL. The results constitute an alternative approach for treating various infectious diseases.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionInstitute of Biomedical Sciences (ICBIM) Federal University of Uberlândia-
Descrição: dc.descriptionInstitute of Biosciences Letters and Exact Sciences (IBILCE) Sao Paulo State University-
Descrição: dc.descriptionFaculty of Medicine (FAMED) Federal University of Uberlândia-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionTechnical School of Health (ESTES) Federal University of Uberlândia-
Descrição: dc.descriptionExact and Technological Sciences Nucleus University of Franca (UNIFRAN)-
Descrição: dc.descriptionPostgraduate Program in Health Promotion University of Franca (UNIFRAN)-
Descrição: dc.descriptionInstitute of Biosciences Letters and Exact Sciences (IBILCE) Sao Paulo State University-
Descrição: dc.descriptionFAPEMIG: 12138-
Descrição: dc.descriptionFAPESP: 2017/04138-8-
Descrição: dc.descriptionCNPq: 307974/2019-7-
Descrição: dc.descriptionCAPES: 88881.506794/2020–01-
Descrição: dc.descriptionFAPEMIG: APQ-01487-22-
Descrição: dc.descriptionFAPEMIG: APQ-03385–18-
Descrição: dc.descriptionCAPES: Finance Code 001-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titlePotential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis-
Tipo de arquivo: dc.typelivro digital-
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