Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira Micheletti, Thayana-
Autor(es): dc.creatorCassia dos Santos, Andressa-
Autor(es): dc.creatorRocha, Guilherme Zweig-
Autor(es): dc.creatorSilva, Vagner Ramon Rodrigues-
Autor(es): dc.creatorQuaresma, Paula Gabriele Fernandes-
Autor(es): dc.creatorAssalin, Heloisa Balan-
Autor(es): dc.creatorJunqueira, Felipe Silva-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorOliveira, Alexandre Gabarra-
Autor(es): dc.creatorSaad, Mario Jose Abdalla-
Autor(es): dc.creatorPrada, Patricia de Oliveira-
Data de aceite: dc.date.accessioned2025-08-21T15:34:58Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:58Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.956116-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246391-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246391-
Descrição: dc.descriptionBackground: Acute exercise contributes to decreased feeding through leptin and interleukin/Janus kinase 2/signal transducers and activators of transcription 3 (IL-6/JAK2/STAT3) signaling. Considering the pleiotropic use of substrates by JAK2 and that JAK2 can phosphorylate the Tubby protein (TUB) in CHO-IR cells, we speculated that acute exercise can activate the IL-6/JAK2/TUB pathway to decrease food intake. Aims: We investigated whether acute exercise induced tyrosine phosphorylation and the association of TUB and JAK2 in the hypothalamus and if IL-6 is involved in this response, whether acute exercise increases the IL-6/TUB axis to regulate feeding, and if leptin has an additive effect over this mechanism. Methods: We applied a combination of genetic, pharmacological, and molecular approaches. Key findings: The in vivo experiments showed that acute exercise increased the tyrosine phosphorylation and association of JAK2/TUB in the hypothalamus, which reduced feeding. This response was dependent on IL-6. Leptin had no additive effect on this mechanism. Significance: The results of this study suggest a novel hypothalamic pathway by which IL-6 released by exercise regulates feeding and reinforces the beneficial effects of exercise.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Applied Sciences State University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Internal Medicine School of Medical Science State University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Physical Education Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education Biosciences Institute São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectfood intake-
Palavras-chave: dc.subjecthypothalamus-
Palavras-chave: dc.subjectIL-6-
Palavras-chave: dc.subjectJAK2-
Palavras-chave: dc.subjectTubby mouse-
Título: dc.titleAcute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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