Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing factor (CRF)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorHogg, David W.-
Autor(es): dc.creatorCasatti, Claudio C.-
Autor(es): dc.creatorBelsham, Denise D.-
Autor(es): dc.creatorBaršytė-Lovejoy, Dalia-
Autor(es): dc.creatorLovejoy, David A.-
Data de aceite: dc.date.accessioned2025-08-21T19:03:53Z-
Data de disponibilização: dc.date.available2025-08-21T19:03:53Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbrep.2022.101397-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246380-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246380-
Descrição: dc.descriptionTeneurin C-terminal associated peptides (TCAP) are natural bioactive peptides that possess anxiety-reducing roles in animals, in vivo, and increase cell viability, in vitro. Although these peptides have some primary structural similarity to corticotropin-releasing factor (CRF), they are derived from the distal extracellular region of the teneurin transmembrane protein where they may act as separate soluble peptides after auto-catalytic cleavage from the teneurin protein following interaction with the cognate teneurin receptor, latrophilin (ADGRL), or expressed as a separate mRNA. However, although the signal transduction mechanism of TCAP in neurons has not been established, previous studies indicate an association with the intracellular calcium flux. Therefore, in this study, we have characterized the TCAP-mediated calcium response in hypothalamic cell lines using single-cell calcium methods with pharmacological antagonists to identify potential calcium channels, in vitro. Under normal circumstances, TCAP-1 reduces cytosolic calcium concentrations by uptake into the mitochondria and efflux through the plasma membrane independently of the teneurins. In doing so, TCAP-1 could inhibit the potential ‘stress’ -inducing actions of CRF.-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada-
Descrição: dc.descriptionDepartment of Cell and Systems Biology University of Toronto-
Descrição: dc.descriptionSao Paulo State University-
Descrição: dc.descriptionDepartment of Physiology University of Toronto-
Descrição: dc.descriptionStructural Genomics Consortium University of Toronto-
Descrição: dc.descriptionDepartment of Toxicology and Physiology University of Toronto-
Descrição: dc.descriptionSao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationBiochemistry and Biophysics Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBenzamil-
Palavras-chave: dc.subjectCalcium-
Palavras-chave: dc.subjectCalcium channel blockers-
Palavras-chave: dc.subjectCorticotropin releasing factor-
Palavras-chave: dc.subjectGPCR-
Palavras-chave: dc.subjectLatrophilin-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectMitochondria-
Palavras-chave: dc.subjectStress-
Palavras-chave: dc.subjectTeneurin-
Palavras-chave: dc.subjectThapsigargin-
Palavras-chave: dc.subjectVanadate-
Título: dc.titleDistal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing factor (CRF)-
Tipo de arquivo: dc.typelivro digital-
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