Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate

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Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversity of Queen-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.creatorCarvajal, Jorge-
Autor(es): dc.creatorCasanello, Paola-
Autor(es): dc.creatorToso, Alberto-
Autor(es): dc.creatorFarías, Marcelo-
Autor(es): dc.creatorCarrasco-Negue, Karina-
Autor(es): dc.creatorAraujo, Kenny-
Autor(es): dc.creatorValero, Paola-
Autor(es): dc.creatorFuenzalida, Javiera-
Autor(es): dc.creatorSolari, Caterina-
Autor(es): dc.creatorSobrevia, Luis-
Data de aceite: dc.date.accessioned2025-08-21T20:25:57Z-
Data de disponibilização: dc.date.available2025-08-21T20:25:57Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2022.166582-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246354-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246354-
Descrição: dc.descriptionThe SARS-CoV-2 infection causes COVID-19 disease, characterized by acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The consequences of maternal SARS-CoV-2 infection for the pregnant woman, fetus, and neonate are controversial. Thus, it is required to determine whether there is viral and non-viral vertical transmission in COVID-19. The disease caused by SARS-CoV-2 leads to functional alterations in asymptomatic and symptomatic pregnant women, the fetoplacental unit and the neonate. Several diseases of pregnancy, including COVID-19, affect the fetoplacental function, which causes in utero programming for young and adult diseases. A generalized inflammatory state and a higher risk of infection are seen in pregnant women with COVID-19. Obesity, diabetes mellitus, and hypertension may increase the vulnerability of pregnant women to infection by SARS-CoV-2. Alpha, Delta, and Omicron variants of SARS-CoV-2 show specific mutations that seem to increase the capacity of the virus to infect the pregnant woman, likely due to increasing its interaction via the virus S protein and angiotensin-converting enzyme 2 receptors. This review shows the literature addressing to what extent COVID-19 in pregnancy affects the pregnant woman, fetoplacental unit, and neonate. Prospective studies that are key in managing SARS-CoV-2 infection in pregnancy are discussed.-
Descrição: dc.descriptionRijksuniversiteit Groningen-
Descrição: dc.descriptionPontificia Universidad Católica de Chile-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionAgencia Nacional de Investigación y Desarrollo-
Descrição: dc.descriptionDepartment of Ob School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Neonatology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Talca-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queen-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology Division of Pathology University of Groningen, University Medical Center Groningen (UMCG), 9713GZ-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionAgencia Nacional de Investigación y Desarrollo: 21221138-
Descrição: dc.descriptionAgencia Nacional de Investigación y Desarrollo: 21221870-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Molecular Basis of Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCovid-19-
Palavras-chave: dc.subjectFetus-
Palavras-chave: dc.subjectNeonate-
Palavras-chave: dc.subjectPlacenta-
Palavras-chave: dc.subjectPregnancy-
Palavras-chave: dc.subjectVirus-
Título: dc.titleFunctional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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