Genomic analysis of a multidrug methicillin-resistant staphylococcus epidermidis recovered from the urine of a guinea pig (Cavia porcellus) with suspected pyelonephritis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFaculdades Integradas Campos Salles-
Autor(es): dc.contributorWildvet Veterinary Clinic-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGaeta, Natália C.-
Autor(es): dc.creatorHellmeister, Alexandre-
Autor(es): dc.creatorPossebon, Fábio S.-
Autor(es): dc.creatorAraujo, João P.-
Autor(es): dc.creatorHeinemann, Marcos B.-
Data de aceite: dc.date.accessioned2025-08-21T16:15:23Z-
Data de disponibilização: dc.date.available2025-08-21T16:15:23Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11259-022-10006-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246223-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246223-
Descrição: dc.descriptionStaphylococcus epidermidis is an emerging pathogen causing infant pyelonephritis. There is a lack of genomic data on Staphylococcus epidermidis as the etiology of pyelonephritis and its resistant determinants. In this study, we have conducted a genomic and microbiologic investigation of an S. epidermidis recovered from the urine of a guinea pig with suspected pyelonephritis in Brazil. The genome was sequenced using the Illumina MiSeq platform and de novo assembled using SPades. Resistome, virulome, and plasmidome were in silico predicted using bioinformatics tools. Data analysis revealed that S. epidermidis USP-LZB-G06 belonged to sequence type ST332. Strikingly, a broad resistome (antibiotics, hazardous heavy metals, and biocides) was predicted, including the presence of the clinically relevant mecA, blaZ, and qacA efflux pump genes. SNP-based analysis revealed that strain USP-LZB-G06 was clustered along mecA positive S. epidermidis strains of ST332 isolated between 2008 and 2016 from humans in Australia and the United States of America. Our results indicate that the detection of this microorganism should be considered as a urinary tract infection agent in exotic pets, particularly guinea pigs. In addition, there is an urgent need to update veterinarians regarding the detection and therapeutic management of these microorganisms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Bacterial Zoonosis Department of Preventive Veterinary Medicine and Animal Health School of Veterinary Medicine and Animal Science University of São Paulo-
Descrição: dc.descriptionFaculdades Integradas Campos Salles-
Descrição: dc.descriptionWildvet Veterinary Clinic-
Descrição: dc.descriptionSão Paulo State University (UNESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2020/15008-0-
Descrição: dc.descriptionCNPq: 310462/2021-5-
Formato: dc.format939-946-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Research Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial resistance-
Palavras-chave: dc.subjectblaZ-
Palavras-chave: dc.subjectCritical pathogens-
Palavras-chave: dc.subjectGenomic surveillance-
Palavras-chave: dc.subjectmecA-
Palavras-chave: dc.subjectOne health-
Título: dc.titleGenomic analysis of a multidrug methicillin-resistant staphylococcus epidermidis recovered from the urine of a guinea pig (Cavia porcellus) with suspected pyelonephritis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.