Development of Biotechnological Photosensitizers for Photodynamic Therapy: Cancer Research and Treatment—From Benchtop to Clinical Practice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.creatorAires-Fernandes, Mariza-
Autor(es): dc.creatorBotelho Costa, Ramon-
Autor(es): dc.creatorRochetti do Amaral, Stéphanie-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorSantos-Ebinuma, Valéria C.-
Autor(es): dc.creatorPrimo, Fernando Lucas-
Data de aceite: dc.date.accessioned2025-08-21T15:39:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:50Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules27206848-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246191-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246191-
Descrição: dc.descriptionPhotodynamic therapy (PDT) is a noninvasive therapeutic approach that has been applied in studies for the treatment of various diseases. In this context, PDT has been suggested as a new therapy or adjuvant therapy to traditional cancer therapy. The mode of action of PDT consists of the generation of singlet oxygen (¹O2) and reactive oxygen species (ROS) through the administration of a compound called photosensitizer (PS), a light source, and molecular oxygen (3O2). This combination generates controlled photochemical reactions (photodynamic mechanisms) that produce ROS, such as singlet oxygen (¹O2), which can induce apoptosis and/or cell death induced by necrosis, degeneration of the tumor vasculature, stimulation of the antitumor immune response, and induction of inflammatory reactions in the illuminated region. However, the traditional compounds used in PDT limit its application. In this context, compounds of biotechnological origin with photosensitizing activity in association with nanotechnology are being used in PDT, aiming at its application in several types of cancer but with less toxicity toward neighboring tissues and better absorption of light for more aggressive types of cancer. In this review, we present studies involving innovatively developed PS that aimed to improve the efficiency of PDT in cancer treatment. Specifically, we focused on the clinical translation and application of PS of natural origin on cancer.-
Descrição: dc.descriptionMajor Projects of Natural Sciences of University in Jiangsu Province of China-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University—UNESP, São Paulo-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University—UNESP, São Paulo-
Descrição: dc.descriptionMajor Projects of Natural Sciences of University in Jiangsu Province of China: 18/2021-
Descrição: dc.descriptionFAPESP: 2020/01604-0-
Descrição: dc.descriptionFAPESP: 2021/06686-8-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiotechnological photosensitizers-
Palavras-chave: dc.subjectcancer therapy-
Palavras-chave: dc.subjectmalignant tumors-
Palavras-chave: dc.subjectnanobiotechnology-
Palavras-chave: dc.subjectphotodynamic therapy-
Título: dc.titleDevelopment of Biotechnological Photosensitizers for Photodynamic Therapy: Cancer Research and Treatment—From Benchtop to Clinical Practice-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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