Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorGovernment College University-
Autor(es): dc.contributorVirtual University of Pakistan-
Autor(es): dc.contributorGovernment College for Women University-
Autor(es): dc.contributorUniversity of Tennessee-
Autor(es): dc.contributorNottingham Trent University-
Autor(es): dc.contributorPrincess Nourah bint Abdulrahman University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBrazil University-
Autor(es): dc.creatorIftikhar, Mehwish-
Autor(es): dc.creatorNoureen, Aasma-
Autor(es): dc.creatorJabeen, Farhat-
Autor(es): dc.creatorUzair, Muhammad-
Autor(es): dc.creatorRehman, Nagina-
Autor(es): dc.creatorSher, Emina Karahmet-
Autor(es): dc.creatorKatubi, Khadijah Mohammedsaleh-
Autor(es): dc.creatorAmérico-Pinheiro, Juliana Heloisa Pinê-
Autor(es): dc.creatorSher, Farooq-
Data de aceite: dc.date.accessioned2025-08-21T21:56:00Z-
Data de disponibilização: dc.date.available2025-08-21T21:56:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2022.136927-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246161-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246161-
Descrição: dc.descriptionNickel nanoparticles (Ni-NPs) have potential applications in high-tech sectors such as battery manufacturing, catalysis, nanotube printing and textile. Apart from their increasing utilisation in daily life, there are concerns about their hazardous nature as they are highly penetrable in biological systems. The carcinogenic and mutagenic ability of Ni-NPs is evident but the research gaps are still there concerning the safety evaluation of Ni-NPs regarding male reproductive ability. This controlled randomized research was planned to assess the male reproductive toxicity of Ni-NPs in Sprague Dawley rats. Ni-NPs of spherical shape and mean particle size of 56 nm were used in the study, characterized by SEM, EDS and XRD. The twenty-five healthy rats (200–220 g) were used for toxicity investigation of Ni-NPs and divided into five groups; negative control (0 Ni-NPs), placebo group (0.9% saline) and three Ni-NPs treated groups (@ 15, 30 and 45 mg/kg BW). The results of 14 days of intraperitoneal exposure to Ni-NPs revealed that a higher dose (45 mg/kg BW) of Ni-NPs caused a significant reduction in body weight, serum testosterone, daily sperm production while the testis index and Ni accumulation and histological changes (necrosis in basement membrane and seminiferous tubules, vacuole formation) in testicular tissues increased with increasing dose of Ni-NPs. It can be concluded from the study that Ni-NPs have potential reproductive toxicity. This study provided the baseline data of Ni-NPs toxicity for the male reproductive system and can be applied for risk assessment in Ni-NPs based products.-
Descrição: dc.descriptionEngineering and Physical Sciences Research Council-
Descrição: dc.descriptionVirtual University of Pakistan-
Descrição: dc.descriptionPrincess Nourah Bint Abdulrahman University-
Descrição: dc.descriptionDepartment of Zoology Government College University-
Descrição: dc.descriptionDepartment of Biology Virtual University of Pakistan-
Descrição: dc.descriptionDepartment of Zoology Government College for Women University-
Descrição: dc.descriptionDepartment of Biochemistry Cellular and Molecular Biology University of Tennessee-
Descrição: dc.descriptionDepartment of Biosciences School of Science and Technology Nottingham Trent University-
Descrição: dc.descriptionDepartment of Chemistry College of Science Princess Nourah bint Abdulrahman University, P.O. Box 84428-
Descrição: dc.descriptionDepartment of Forest Science Soils and Environment School of Agronomic Sciences São Paulo State University (UNESP) Ave. Universitária, 3780, SP-
Descrição: dc.descriptionGraduate Program in Environmental Sciences Brazil University, Street Carolina Fonseca, 584, SP-
Descrição: dc.descriptionDepartment of Engineering School of Science and Technology Nottingham Trent University, Nottingham NG11 8NS-
Descrição: dc.descriptionDepartment of Forest Science Soils and Environment School of Agronomic Sciences São Paulo State University (UNESP) Ave. Universitária, 3780, SP-
Descrição: dc.descriptionPrincess Nourah Bint Abdulrahman University: PNURSP2022R26-
Idioma: dc.languageen-
Relação: dc.relationChemosphere-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHistological alterations and lipid peroxidation-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectReproductive toxicity-
Palavras-chave: dc.subjectSerum testosterone-
Palavras-chave: dc.subjectSperm production-
Título: dc.titleBioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.