Fipronil impairs the GABAergic brain responses of Nile Tilapia during the transition from normoxia to acute hypoxia

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorFundação Universidade Regional de Blumenau-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorDourado, Priscila L. R.-
Autor(es): dc.creatorLima, Daína-
Autor(es): dc.creatorMattos, Jacó J.-
Autor(es): dc.creatorBainy, Afonso C. D.-
Autor(es): dc.creatorGrott, Suelen C.-
Autor(es): dc.creatorAlves, Thiago C.-
Autor(es): dc.creatorde Almeida, Eduardo Alves-
Autor(es): dc.creatorda Silva, Danilo G. Humberto-
Data de aceite: dc.date.accessioned2025-08-21T22:57:15Z-
Data de disponibilização: dc.date.available2025-08-21T22:57:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jez.2662-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246037-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246037-
Descrição: dc.descriptionγ-aminobutyric acid (GABA) is one of the main neurotransmitters involved in the adaptation processes against the damage that hypoxia can cause to the brain. Due to its antagonist action on GABA receptors, the insecticide fipronil can turn the fish more susceptible to the negative effects of hypoxia. This study aimed to understand better if fipronil affects these GABAergic responses of Tilapia ahead to hypoxia. Oreochromis Niloticus (Nile Tilapia) were exposed for 3 and 8 h to fipronil (0.0, 0.1, and 0.5 µg.L−1) under normoxia (dissolved O2 > 6 mg.L−1) and moderate hypoxia (dissolved O2 < 2 mg.L−1) conditions. Briefly, hypoxia caused opposite effects on the gene transcription of the evaluated ionotropic and metabotropic GABA receptors. Unexpectedly, we obtained reduced HIF1A mRNA and brain GABA levels, mostly in the first 3 h of the experiment, for the hypoxic group compared with the normoxia one. Besides that, we also demonstrated that the insecticide fipronil impairs the brain GABAergic signaling of a hypoxia-tolerant fish during the transition from a normoxic to an acute hypoxic state. Thus, these results predict the relevant impact on the brain metabolic adaptations of fishes exposed to such stressful conditions in an aquatic environment, as well as the effects of fipronil in the GABAergic responses to hypoxia, which in turn may have ecological and physiological significance to hypoxia-tolerant fishes exposed to this insecticide.-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of Santa Catarina UFSC, SC-
Descrição: dc.descriptionDepartment of Natural Sciences FURB Fundação Universidade Regional de Blumenau-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso do Sul (CPTL/UFMS), Campus de Três Lagoas, Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences São Paulo State University (UNESP)-
Formato: dc.format138-152-
Idioma: dc.languageen-
Relação: dc.relationJournal of Experimental Zoology Part A: Ecological and Integrative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant enzymes-
Palavras-chave: dc.subjectFipronil-
Palavras-chave: dc.subjectFish-
Palavras-chave: dc.subjectGABA receptors-
Palavras-chave: dc.subjectHIF-1A-
Título: dc.titleFipronil impairs the GABAergic brain responses of Nile Tilapia during the transition from normoxia to acute hypoxia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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