The Mycophenolate-based Immunosuppressive Regimen Is Associated with Increased Mortality in Kidney Transplant Patients with COVID-19

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFundação Oswaldo Ramos-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal Do Ceará-
Autor(es): dc.contributorHospital Universitário Walter Cantídio-
Autor(es): dc.contributorHospital Geral de Fortaleza-
Autor(es): dc.contributorSanta Casa de Misericórdia de Porto Alegre-
Autor(es): dc.contributorFederal University of Rio Grande-
Autor(es): dc.contributorHospital Santa Isabel-
Autor(es): dc.contributorSanta Casa de Misericórdia de Juiz de for A-
Autor(es): dc.contributorOnofre Lopes University Hospital-
Autor(es): dc.contributorMedical School FAMERP-
Autor(es): dc.contributorHospital Municipal São José (HMSJ)-
Autor(es): dc.contributorHospital Universitário da UFMA-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorHospital Marcio Cunha-
Autor(es): dc.creatorRequião-Moura, Lúcio R.-
Autor(es): dc.creatorDe Andrade, Luís Gustavo Modelli-
Autor(es): dc.creatorDe Sandes-Freitas, Tainá Veras-
Autor(es): dc.creatorCristelli, Marina Pontello-
Autor(es): dc.creatorViana, Laila Almeida-
Autor(es): dc.creatorNakamura, Mônica Rika-
Autor(es): dc.creatorGarcia, Valter Duro-
Autor(es): dc.creatorManfro, Roberto Ceratti-
Autor(es): dc.creatorSimão, Denise Rodrigues-
Autor(es): dc.creatorDe Barros Almeida, Ricardo Augusto Monteiro-
Autor(es): dc.creatorFerreira, Gustavo Fernandes-
Autor(es): dc.creatorCosta, Kellen Micheline Alves Henrique-
Autor(es): dc.creatorDe Lima, Paula Roberta-
Autor(es): dc.creatorPacheco-Silva, Alvaro-
Autor(es): dc.creatorCharpiot, Ida Maria Maximina Fernandes-
Autor(es): dc.creatorDeboni, Luciane Mônica-
Autor(es): dc.creatorFerreira, Teresa Cristina Alves-
Autor(es): dc.creatorMazzali, Marilda-
Autor(es): dc.creatorCalazans, Carlos Alberto Chalabi-
Autor(es): dc.creatorOriá, Reinaldo Barreto-
Autor(es): dc.creatorTedesco-Silva, Hélio-
Autor(es): dc.creatorMedina-Pestana, José-
Autor(es): dc.creatorDe Oliveira, Claudia Maria Costa-
Autor(es): dc.creatorEsmeraldo, Ronaldo De Matos-
Autor(es): dc.creatorBaptista, Maria Alice Sperto Ferreira-
Autor(es): dc.creatorDe Sousa, Marcos Vinícius-
Autor(es): dc.creatorDe Mello Santana, Viviane Brandão Bandeira-
Autor(es): dc.creatorRomão, Elen Almeida-
Autor(es): dc.creatorZanocco, Juliana Aparecida-
Autor(es): dc.creatorBignelli, Alexandre Tortoza-
Autor(es): dc.creatorDe Boni Monteiro De Carvalho, Deise-
Autor(es): dc.creatorDe Lourdes Noronha, Irene-
Autor(es): dc.creatorDa Rocha Saldanha, Anita Leme-
Autor(es): dc.creatorRomao, Joao Egídio-
Autor(es): dc.creatorArimatea, Gustavo Guilherme Queiroz-
Autor(es): dc.creatorLasmar, Marcus Faria-
Autor(es): dc.creatorRioja, Suzimar Da Silveira-
Autor(es): dc.creatorKroth, Leonardo Viliano-
Autor(es): dc.creatorMadeira, Rafael Lage-
Autor(es): dc.creatorMiorin, Luiz Antônio-
Autor(es): dc.creatorMalafronte, Patrícia-
Autor(es): dc.creatorPozzi, Carolina Maria-
Autor(es): dc.creatorPinheiro, Helady Sanders-
Autor(es): dc.creatorMaciel, Rafael Fabio-
Autor(es): dc.creatorDa Fonte Andrade, Larissa Guedes-
Autor(es): dc.creatorFilho, Lauro Monteiro Vasconcellos-
Autor(es): dc.creatorDe Carvalho Contieri, Fabiana Loss-
Autor(es): dc.creatorNeves, Carolina Lara-
Autor(es): dc.creatorPereira, André Barreto-
Autor(es): dc.creatorSilva, Amanda Maíra Damasceno-
Autor(es): dc.creatorPalma, Lilian Monteiro Pereira-
Autor(es): dc.creatorDe Souza, Pedro Augusto Macedo-
Autor(es): dc.creatorMachado, David José Barros-
Autor(es): dc.creatorSaber, Luciana Tanajura Santamaria-
Data de aceite: dc.date.accessioned2025-08-21T16:16:34Z-
Data de disponibilização: dc.date.available2025-08-21T16:16:34Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/TP.0000000000004251-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246030-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246030-
Descrição: dc.descriptionBackground. The chronic use of immunosuppressive drugs is a key risk factor of death because of coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTRs), although no evident association between the class of immunosuppressive and outcomes has been observed. Thus, we aimed to compare COVID-19-associated outcomes among KTRs receiving 3 different immunosuppressive maintenance regimes. Methods. This study included data from 1833 KTRs with COVID-19 diagnosed between March 20 and April 21 extracted from the national registry before immunization. All patients were taking calcineurin inhibitor associated with mycophenolate acid (MPA, n = 1258), azathioprine (AZA, n = 389), or mammalian targets of rapamycin inhibitors (mTORi, n = 186). Outcomes within 30 and 90 d were assessed. Results. Compared with patients receiving MPA, the 30-d (79.9% versus 87.9% versus 89.2%; P < 0.0001) and 90-d (75% versus 83.5% versus 88.2%; P < 0.0001) unadjusted patient survivals were higher in those receiving AZA or mTORi, respectively. Using adjusted multivariable Cox regression, compared with patients receiving AZA, the use of MPA was associated with a higher risk of death within 30 d (adjusted hazard ratio [aHR], 1.70; 95% confidence interval [CI], 1.21-2.40; P = 0.003), which was not observed in patients using mTORi (aHR, 0.78; 95% CI, 0.45-1.35; P = 0.365). At 90 d, although higher risk of death was confirmed in patients receiving MPA (aHR, 1.46; 95% CI, 1.09-1.98; P = 0.013), a reduced risk was observed in patients receiving mTORi (aHR, 0.59; 95% CI, 0.35-0.97; P = 0.04) compared with AZA. Conclusions. This national cohort data suggest that, in KTRs receiving calcineurin inhibitor and diagnosed with COVID-19, the use of MPA was associated with higher risk of death, whereas mTORi use was associated with lower risk of death.-
Descrição: dc.descriptionNephrology Division Department of Medicine Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Transplantation Hospital Do Rim Fundação Oswaldo Ramos-
Descrição: dc.descriptionRenal Transplant Unit Hospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartment of Internal Medicine Universidade Estadual Paulista-UNESP-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Médicas Departamento de Medicina Clínica Faculdade de Medicina Universidade Federal Do Ceará-
Descrição: dc.descriptionHospital Universitário Walter Cantídio-
Descrição: dc.descriptionHospital Geral de Fortaleza-
Descrição: dc.descriptionSanta Casa de Misericórdia de Porto Alegre-
Descrição: dc.descriptionHospital de Clínicas de Porto Alegre Federal University of Rio Grande-
Descrição: dc.descriptionHospital Santa Isabel-
Descrição: dc.descriptionSanta Casa de Misericórdia de Juiz de for A-
Descrição: dc.descriptionDivision of Nephrology and Kidney Transplantation Onofre Lopes University Hospital-
Descrição: dc.descriptionHospital de Base Medical School FAMERP-
Descrição: dc.descriptionHospital Municipal São José (HMSJ)-
Descrição: dc.descriptionHospital Universitário da UFMA-
Descrição: dc.descriptionRenal Transplant Research Laboratory Renal Transplant Unit Division of Nephrology School of Medical Sciences University of Campinas Ͽ UNICAMP-
Descrição: dc.descriptionHospital Marcio Cunha-
Descrição: dc.descriptionDepartment of Internal Medicine Universidade Estadual Paulista-UNESP-
Formato: dc.formatE441-E451-
Idioma: dc.languageen-
Relação: dc.relationTransplantation-
???dc.source???: dc.sourceScopus-
Título: dc.titleThe Mycophenolate-based Immunosuppressive Regimen Is Associated with Increased Mortality in Kidney Transplant Patients with COVID-19-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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