Molecular characterization and sequecing analysis of SARS-CoV-2 genome in Minas Gerais, Brazil

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Oxford-
Autor(es): dc.contributorFederal University of Triângulo Mineiro-
Autor(es): dc.contributorDiagnósticos do Brasil-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.creatorFerreira, Giulia Magalhães-
Autor(es): dc.creatorClaro, Ingra Morales-
Autor(es): dc.creatorGrosche, Victória Riquena-
Autor(es): dc.creatorCândido, Darlan-
Autor(es): dc.creatorJosé, Diego Pandeló-
Autor(es): dc.creatorRocha, Esmenia Coelho-
Autor(es): dc.creatorde Moura Coletti, Thaís-
Autor(es): dc.creatorManuli, Erika Regina-
Autor(es): dc.creatorGaburo, Nelson-
Autor(es): dc.creatorFaria, Nuno Rodrigues-
Autor(es): dc.creatorSabino, Ester Cerdeira-
Autor(es): dc.creatorde Jesus, Jaqueline Goes-
Autor(es): dc.creatorJardim, Ana Carolina Gomes-
Data de aceite: dc.date.accessioned2025-08-21T16:02:59Z-
Data de disponibilização: dc.date.available2025-08-21T16:02:59Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biologicals.2022.08.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245990-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245990-
Descrição: dc.descriptionThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, is the causative agent of the coronavirus disease 2019 (COVID-19). Since its first notification in São Paulo state (SP) on 26th February 2020, more than 22,300,000 cases and 619,000 deaths were reported in Brazil. In early pandemic, SARS-CoV-2 spread locally, however, over time, this virus was disseminated to other regions of the country. Herein, we performed genomic sequencing and phylogenetic analysis of SARS-CoV-2 using 20 clinical samples of COVID-19 confirmed cases from 9 cities of Minas Gerais state (MG), in order to evaluate the molecular properties of circulating viral strains in this locality from March to May 2020. Our analyses demonstrated the circulation of B.1 lineage isolates in the investigated locations and nucleotide substitutions were observed into the genomic regions related to important viral structures. Additionally, sequences generated in this study clustered with isolates from SP, suggesting a dissemination route between these two states. Alternatively, monophyletic groups of sequences from MG and other states or country were observed, indicating independent events of virus introduction. These results reinforce the need of genomic surveillance for understand the ongoing spread of emerging viral pathogens.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Zoology, University of Oxford-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biomedical Science Federal University of Uberlândia, MG-
Descrição: dc.descriptionInstitute of Tropical Medicine University of São Paulo Medical School-
Descrição: dc.descriptionDepartment of Infectious and Parasitic Diseases University of São Paulo Medical School-
Descrição: dc.descriptionInstitute of Bioscience Humanities and Exact Sciences São Paulo State University São José do Rio Preto-
Descrição: dc.descriptionDepartment of Zoology University of Oxford-
Descrição: dc.descriptionFederal University of Triângulo Mineiro, MG-
Descrição: dc.descriptionDB Diagnósticos do Brasil-
Descrição: dc.descriptionMCR Centre for Global Infectious Disease Analysis J-IDEA Imperial College London-
Descrição: dc.descriptionInstitute of Bioscience Humanities and Exact Sciences São Paulo State University São José do Rio Preto-
Descrição: dc.descriptionDepartment of Zoology, University of Oxford: 001-
Descrição: dc.descriptionFAPESP: 2018/17176-8-
Descrição: dc.descriptionFAPESP: 2019/12000-1-
Formato: dc.format43-52-
Idioma: dc.languageen-
Relação: dc.relationBiologicals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectB.1 lineage-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectGenome sequencing-
Palavras-chave: dc.subjectGenomic surveillance-
Palavras-chave: dc.subjectMinas gerais-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleMolecular characterization and sequecing analysis of SARS-CoV-2 genome in Minas Gerais, Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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