Experimental data and thermodynamic modeling of the CO2 + Acetone + Efavirenz system at high pressures

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorCiência e Tecnologia Goiano-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorResearch Center-
Autor(es): dc.creatorde Souza, Guilherme Botelho Meireles-
Autor(es): dc.creatorde Araujo, Paulo Cardozo Carvalho-
Autor(es): dc.creatorRocha, Helvécio Vinícius Antunes-
Autor(es): dc.creatorFavareto, Rogerio-
Autor(es): dc.creatorFreire, Nian Vieira-
Autor(es): dc.creatorArce, Pedro Felipe-
Autor(es): dc.creatorFerreira-Pinto, Leandro-
Autor(es): dc.creatorCardozo-Filho, Lucio-
Data de aceite: dc.date.accessioned2025-08-21T15:19:29Z-
Data de disponibilização: dc.date.available2025-08-21T15:19:29Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jct.2022.106924-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245976-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245976-
Descrição: dc.descriptionIt is important to understand the fluid phase behavior of the systems containing CO2, acetone, and Efavirenz for processes that use supercritical fluids to produce micro and/or nanoparticles for drug encapsulation. Thus, the purpose of this work is to measure experimentally data on the phase transitions of CO2 + Efavirenz and CO2 + acetone + Efavirenz systems using the visual static synthetic method and a variable-volume cell integrated into the experimental equipment. The experimental settings for the binary system were: pressures up to 16 MPa, temperatures of 333.15, 338.15, and 343.15 K, and the global Efavirenz mole fraction from 4 × 10−5 up to 15 × 10−5. The experimental settings for the ternary system were: pressure up to 10 MPa, temperatures from 303.15 to 333.15 K, and the global CO2 mole fraction from 0.2 up to 0.9. For the binary systems, the observed phase transitions are solid–fluid transitions; for the ternary systems, the observed phase transitions are bubble point (BP) transitions. Thermodynamic simulations using the Group Contribution Volume-Translated Peng-Robinson (GC-VT-PR) and Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT) equations of state (EoS) demonstrated a striking correlation with experimental data. The relative deviations from pressure and temperature corroborate the efficiency of the thermodynamic models used in this work.-
Descrição: dc.descriptionState University of Maringá Department of Chemical Engineering, PR-
Descrição: dc.descriptionLaboratory of Micro and Nanotechnology Institute of Technology of Drugs Oswaldo Cruz Foundation-
Descrição: dc.descriptionInstituto Federal de Educação Ciência e Tecnologia Goiano, Campus Rio Verde, GO-
Descrição: dc.descriptionUniversity of São Paulo Engineering School of Lorena Department of Chemical Engineering, SP-
Descrição: dc.descriptionSao Paulo State University (UNESP) Faculty of Engineering and Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP), Campus of São João da Boa Vista, SP-
Descrição: dc.descriptionCentro Universitario da Fundaçao de Ensino Octavio Bastos (UNIFEOB) Research Center, São João da Boa Vista, SP-
Descrição: dc.descriptionSao Paulo State University (UNESP) Faculty of Engineering and Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP), Campus of São João da Boa Vista, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Chemical Thermodynamics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetone-
Palavras-chave: dc.subjectEfavirenz-
Palavras-chave: dc.subjectFluid Phase equilibrium-
Palavras-chave: dc.subjectsupercritical CO2-
Título: dc.titleExperimental data and thermodynamic modeling of the CO2 + Acetone + Efavirenz system at high pressures-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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