Fluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Study

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Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMatos-Sousa, José Mário-
Autor(es): dc.creatorBittencourt, Leonardo Oliveira-
Autor(es): dc.creatorFerreira, Maria Karolina Martins-
Autor(es): dc.creatordos Santos, Vinicius Ruan Neves-
Autor(es): dc.creatorBalbinot, Karolyny Martins-
Autor(es): dc.creatorAlves-Júnior, Sérgio-
Autor(es): dc.creatorPinheiro, João de Jesus Viana-
Autor(es): dc.creatorCharone, Senda-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorLima, Rafael Rodrigues-
Data de aceite: dc.date.accessioned2025-08-21T18:03:11Z-
Data de disponibilização: dc.date.available2025-08-21T18:03:11Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jcm11185373-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245972-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245972-
Descrição: dc.descriptionDespite a strong body of evidence attesting to the effectiveness of fluoride (F) in preventing and controlling caries, some studies have sought to investigate the influence of F exposure on the salivary glands, organs that are essential for the maintenance of cavity homeostasis through salivary production, finding that exposure to F can cause biochemical and proteomic changes. Thus, this study aimed to investigate the morphological effects of prolonged exposure to F on the salivary glands of mice, at concentrations that would correspond to optimally fluoridated water (suitable for human consumption) and to fluorosis-endemic regions. Twenty-four male mice (Mus musculus) were divided into three groups, according to F levels in the drinking water: 0 (control), 10, or 50 mg F/L, with an exposure period of 60 days. The glands were morphometrically analyzed for the total acinar area, parenchyma area, and stromal area, as well as for the immunohistochemical analysis of myoepithelial cells. The results showed that prolonged exposure to F at 10 mg F/L did not promote significant changes in the morphometry of the salivary glands of mice, which reinforces the safety of the chronic use of F in low doses.-
Descrição: dc.descriptionLaboratory of Functional and Structural Biology Institute of Biological Sciences Federal University of Pará, PA-
Descrição: dc.descriptionSchool of Dentistry Federal University of Pará, PA-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Clinical Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectsalivary glands-
Palavras-chave: dc.subjectsodium fluoride-
Título: dc.titleFluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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