The Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study

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Autor(es): dc.contributorFederal University of Piauí-
Autor(es): dc.contributorUniversity of Aberdeen-
Autor(es): dc.contributorFederal Institute of Maranhão-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal Institute of Piaui-
Autor(es): dc.contributorFederal University of Goias-
Autor(es): dc.creatorAlves, Patrícia e Silva-
Autor(es): dc.creatorPreet, Gagan-
Autor(es): dc.creatorDias, Leandro-
Autor(es): dc.creatorOliveira, Maria-
Autor(es): dc.creatorSilva, Rafael-
Autor(es): dc.creatorCastro, Isione-
Autor(es): dc.creatorSilva, Giovanna-
Autor(es): dc.creatorJúnior, Joaquim-
Autor(es): dc.creatorLima, Nerilson-
Autor(es): dc.creatorSilva, Dulce Helena-
Autor(es): dc.creatorAndrade, Teresinha-
Autor(es): dc.creatorJaspars, Marcel-
Autor(es): dc.creatorFeitosa, Chistiane-
Data de aceite: dc.date.accessioned2025-08-21T17:06:22Z-
Data de disponibilização: dc.date.available2025-08-21T17:06:22Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules27186016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245969-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245969-
Descrição: dc.descriptionIn this work, a metabolic profile of Mansoa hirsuta was investigated, and in vitro assays and theoretical approaches were carried out to evaluate its antioxidant potential. The phytochemical screening detected saponins, organic acids, phenols, tannins, flavonoids, and alkaloids in extracts of leaves, branches, and roots. Through LC-MS analysis, the triterpenes oleanolic acid (m/z 455 [M-H]−) and ursolic acid (m/z 455 [M-H]−) were identified as the main bioactive components. The extracts of the leaves, branches, and roots revealed moderate antioxidant potential in the DPPH test and all extracts were more active in the ABTS test. The leaf extracts showed better antioxidant capacity, displaying IC50 values of 43.5 ± 0.14, 63.6 ± 0.54, and 56.1 ± 0.05 µg mL−1 for DPPH, ABTS, and kinetics assays, respectively. The leaf extract showed higher total flavonoid content (TFC) (5.12 ± 1.02 mg QR/g), followed by branches (3.16 ± 0.88 QR/g) and roots (2.04 ± 0.52 QR/g/g). The extract of the branches exhibited higher total phenolic content (TPC) (1.07 ± 0.77 GAE/g), followed by leaves (0.58 ± 0.30 GAE/g) and roots (0.19 ± 0.47 GAE/g). Pharmacophore and molecular docking analysis were performed in order to better understand the potential mechanism of the antioxidant activity of its major metabolites.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPost-Graduation Department in Chemistry Federal University of Piauí-
Descrição: dc.descriptionMarine Biodiscovery Centre Department of Chemistry University of Aberdeen-
Descrição: dc.descriptionNucleus of Applied Research to Sciences (NIAC) Federal Institute of Maranhão, Campus Presidente Dutra-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Federal University of Piauí-
Descrição: dc.descriptionDepartment of Chemistry Federal Institute of Piaui-
Descrição: dc.descriptionChemistry Institute Federal University of Goias, Campus Samambaia-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University-
Descrição: dc.descriptionCNPq: 316647/2020-9-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectMansoa hirsuta-
Palavras-chave: dc.subjectmolecular docking-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectpharmacophore-
Palavras-chave: dc.subjecttriterpenes-
Título: dc.titleThe Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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