Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Santo Amaro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSakalem, Marna Eliana-
Autor(es): dc.creatorTabach, Ricardo-
Autor(es): dc.creatorde Oliveira, Miriane-
Autor(es): dc.creatorCarlini, Elisaldo Araújo-
Data de aceite: dc.date.accessioned2025-08-21T17:32:43Z-
Data de disponibilização: dc.date.available2025-08-21T17:32:43Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1871524922666220426102650-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245905-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245905-
Descrição: dc.descriptionBackground: There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects. Objective: In this study, we performed an interspecific pharmacological comparison of five inves-tigated Passiflora species, all native to Brazil, namely P. bahiensis, P. coccinea, P. quadrangu-laris, P. sidaefolia, and P. vitifolia. Methods: Extracts were administered to mice before behavioral testing, including a general pharmacological screening and anxiolytic-like effect investigation. Results: Three of the species (P. coccinea, P. quadrangularis, and P. sidaefolia) induced a de-crease in locomotor activity of mice; P. coccinea also reduced the latency to sleep. Importantly, none of the species interfered with motor coordination. Oral administration evoked no severe signs of toxicity, even at higher doses. Regarding the anxiolytic-like profile, P. sidaefolia reduced the anxious-like behavior in the Holeboard test in a similar way to the positive control, Passiflora incarnata, while not affecting total motricity. Conclusion: These results indicated that P. coccinea, P. quadrangularis, and P. sidaefolia reduced the general activity of mice and conferred a calmative/sedative potential to these three spe-cies, which must be further elucidated by future investigations.-
Descrição: dc.descriptionArmed Forces Institute of Pathology-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Psychobiology Universidade Federal de Sao Paulo (UNIFESP), SP-
Descrição: dc.descriptionUniversidade Santo Amaro, SP-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 08-51114-8-
Formato: dc.format125-138-
Idioma: dc.languageen-
Relação: dc.relationCentral Nervous System Agents in Medicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanxiolytic-like effect-
Palavras-chave: dc.subjecthole-board-
Palavras-chave: dc.subjectmaracuja-
Palavras-chave: dc.subjectmedicinal plants-
Palavras-chave: dc.subjectPassifloreaceae-
Palavras-chave: dc.subjectpassionflower-
Palavras-chave: dc.subjectpharmacological screening-
Palavras-chave: dc.subjectphytomedicine-
Título: dc.titleBehavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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