Susceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPozzato, Laura Bernardo-
Autor(es): dc.creatorda Silva, Rafaela Alves-
Autor(es): dc.creatorSaldanha, Luiz Leonardo-
Autor(es): dc.creatorNeppelenbroek, Karin Hermana-
Autor(es): dc.creatorDokkedal, Anne Lígia-
Autor(es): dc.creatorLara, Vanessa Soares-
Autor(es): dc.creatorPorto, Vinicius Carvalho-
Data de aceite: dc.date.accessioned2025-08-21T19:17:34Z-
Data de disponibilização: dc.date.available2025-08-21T19:17:34Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2018-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245871-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245871-
Descrição: dc.descriptionPunica granatum L. (Lythraceae) is traditionally used to treat various diseases. Due to the resistance of Candida albicans biofilms to conventional treatments, natural products have been extensively studied. The increase of cell surface hydrophobicity (CSH) has been related to an increment in fungal resistance and virulence. This study evaluated the susceptibility and CSH of C. albicans clinical isolate after exposure to P. granatum, in order to establish whether there is correlation between the two properties. P. granatum showed a fungistatic activity (MIC50 – 8 and 12 mg/ml) (MIC90 – 25 mg/ml). Exposure to 4, 8 and 25 mg/ml did not change fungal CSH. Anti-Candida activity of P. granatum was observed for up to 48 h, indicating that the extract possess a therapeutic potential for treatment and prevention of oral infections, such as denture stomatitis. Also, their fungistatic action was associated with maintenance of the cell wall hydrophilicity of the fungus.-
Descrição: dc.descriptionBauru School of Dentistry University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP), SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics Bauru School of Dentistry University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences Faculty of Sciences São Paulo State University (UNESP), São Paulo-
Formato: dc.format75-82-
Idioma: dc.languageen-
Relação: dc.relationRevista Brasileira de Plantas Medicinais-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal activity-
Palavras-chave: dc.subjectBiofilms-
Palavras-chave: dc.subjectDenture Stomatitis-
Palavras-chave: dc.subjectMicrobial Sensitivity Tests-
Palavras-chave: dc.subjectPunica granatum-
Título: dc.titleSusceptibility of Candida albicans to Punica granatum and correlation with cell surface hydrophobicity-
Título: dc.titleSusceptibilidade de Candida albicans à Punica granatum e correlação com a hidrofobicidade de superfície celular-
Tipo de arquivo: dc.typelivro digital-
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