Design of rapamycin and resveratrol coloaded liposomal formulation for breast cancer therapy

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBarretos Canc Hosp-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorFundacao Oswaldo Cruz-
Autor(es): dc.creatorReis, Leidiana Rocha dos-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorSabio, Rafael M.-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorDi Filippo, Leonardo Delello-
Autor(es): dc.creatorDuarte, Jonatas Lobato-
Autor(es): dc.creatorFernandes, Ligia de Souza-
Autor(es): dc.creatorAraujo, Victor H. Sousa-
Autor(es): dc.creatorSilva, Viviane Aline Oliveira-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T20:19:21Z-
Data de disponibilização: dc.date.available2025-08-21T20:19:21Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-18-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/nnm-2022-0227-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245829-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245829-
Descrição: dc.descriptionAims: The development of rapamycin (RAP) and resveratrol (RSV) coloaded liposomes (RAP-RSV-LIP) for breast cancer therapy. Materials & methods: Liposomes were prepared using a high-pressure homogenization technique and evaluated according to their physicochemical characteristics, cellular uptake and cytotoxicity against tumoral and normal cells. Results & conclusion: The RAP-RSV-LIP showed negative surface charge, size around 100 nm, low polydispersity and high encapsulation efficiency for RAP and RSV (58.87 and 63.22%, respectively). RAP-RSV-LIP showed great stability over 60 days and a prolonged drug release profile. In vitro studies indicated that RAP-RSV-LIP were internalized in an estrogen receptor-positive human breast cancer cell line (MCF-7, 34.2%) and improved cytotoxicity when compared with free drugs. Therefore RAP-RSV-LIP showed great antitumoral potential against breast cancer cells.-
Descrição: dc.descriptionCoordena��o de Aperfei�oamento de Pessoal de N�vel Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionBarretos Canc Hosp, Mol Oncol Res Ctr, Antenor Duarte Villela St,1331, BR-14784400 Barretos, SP, Brazil-
Descrição: dc.descriptionUniv Fed Bahia, Med Sch, Dept Pathol & Legal Med, BR-40026010 Salvador, BA, Brazil-
Descrição: dc.descriptionFundacao Oswaldo Cruz, Goncalo Moniz Inst, Lab Pathol & Mol Biol, BR-40296710 Salvador, BA, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format13-
Idioma: dc.languageen-
Publicador: dc.publisherFuture Medicine Ltd-
Relação: dc.relationNanomedicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectcodelivery-
Palavras-chave: dc.subjectdrug-delivery systems-
Palavras-chave: dc.subjectenhanced permeability and retention effect-
Palavras-chave: dc.subjecthigh-pressure homogenization-
Palavras-chave: dc.subjectliposomes-
Palavras-chave: dc.subjectnanomedicines-
Palavras-chave: dc.subjectnanoparticles-
Palavras-chave: dc.subjectnanotechnology-
Palavras-chave: dc.subjectpassive targeting-
Título: dc.titleDesign of rapamycin and resveratrol coloaded liposomal formulation for breast cancer therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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