Propolis anti-inflammatory effects on MAGE-1 and retinoic acid-treated dendritic cells and on Th1 and T regulatory cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Coimbra-
Autor(es): dc.creatorSantiago, Karina Basso-
Autor(es): dc.creatorConti, Bruno Jose-
Autor(es): dc.creatorCardoso, Eliza de Oliveira-
Autor(es): dc.creatorConte, Fernanda Lopes-
Autor(es): dc.creatorTasca, Karen Ingrid-
Autor(es): dc.creatorRomagnoli, Graziela Gorete-
Autor(es): dc.creatorGolim, Marjorie de Assis-
Autor(es): dc.creatorCruz, Maria Tereza-
Autor(es): dc.creatorSforcin, Jose Mauricio-
Data de aceite: dc.date.accessioned2025-08-21T18:50:14Z-
Data de disponibilização: dc.date.available2025-08-21T18:50:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0044-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245797-
Descrição: dc.descriptionBackground: Propolis exhibits huge potential in the pharmaceutical industry. In the present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) and on T lymphocytes to observe a possible differential activation of T lymphocytes, driving preferentially to Th1 or Treg cells.Methods: Cell viability, lymphocyte proliferation, gene expression (T-bet and FoxP3), and cytokine production by DCs (TNF-alpha, IL-10, IL-6 and IL-1 beta) and lymphocytes (IFN-gamma and TGF-beta) were analyzed.Results: MAGE-1 and RA alone or in combination with propolis inhibited TNF-alpha production and induced a higher lymphoproliferation compared to control, while MAGE-1 + propolis induced IL-6 production. Propolis in combination with RA induced FoxP3 expression. MAGE-1 induced IFN-gamma production while propolis inhibited it, returning to basal levels. RA inhibited TGF-beta production, what was counteracted by propolis.Conclusion: Propolis affected immunological parameters inhibiting pro-inflammatory cytokines and favoring the regulatory profile, opening perspectives for the control of inflammatory conditions.-
Descrição: dc.descriptionFunda��o de Amparo � Pesquisa do Estado de S�o Paulo (FAPESP)-
Descrição: dc.descriptionCoordena��o de Aperfei�oamento de Pessoal de N�vel Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Med FMB, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Coimbra, Fac Pharm, Ctr Neurosci & Cellular Biol, Coimbra, Portugal-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Med FMB, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2015/03493-3-
Descrição: dc.descriptionFAPESP: 2015/02596-3-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherCevap-sao Paulo State Univ-unesp-
Relação: dc.relationJournal Of Venomous Animals And Toxins Including Tropical Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectDendritic cells-
Palavras-chave: dc.subjectT CD4+cells-
Palavras-chave: dc.subjectMAGE-1-
Palavras-chave: dc.subjectRetinoic acid-
Palavras-chave: dc.subjectPropolis-
Palavras-chave: dc.subjectImmunomodulation-
Título: dc.titlePropolis anti-inflammatory effects on MAGE-1 and retinoic acid-treated dendritic cells and on Th1 and T regulatory cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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