Retrospective Analysis of the SARS-CoV-2 Infection Profile in COVID-19 Positive Patients in Vitoria da Conquista, Northeast Brazil

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Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorMunicipal Cent Lab-
Autor(es): dc.contributorUniv Estadual Santa Cruz-
Autor(es): dc.contributorOswaldo Cruz Inst Fiocruz-
Autor(es): dc.contributorNortheast Independent Coll-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Campus Biomed Roma-
Autor(es): dc.contributorBahia Sch Med & Publ Heath-
Autor(es): dc.contributorPan Amer Hlth Org-
Autor(es): dc.creatorDantas, Anna Carolina S.-
Autor(es): dc.creatorOliveira, Hellen B. M.-
Autor(es): dc.creatorGomes, Camila P.-
Autor(es): dc.creatorAlves, Daniele L.-
Autor(es): dc.creatorInfante, Priscilla D. B.-
Autor(es): dc.creatorCaitite, Rosimara de J. A.-
Autor(es): dc.creatorFritsch, Hegger M.-
Autor(es): dc.creatorCucco, Marina S.-
Autor(es): dc.creatorSilva, Lucas S. C.-
Autor(es): dc.creatorOliveira, Caline N. T.-
Autor(es): dc.creatorBittencourt, Rafaela de S.-
Autor(es): dc.creatorAmorim, Aline T.-
Autor(es): dc.creatorNascimento, Ana Luisa P.-
Autor(es): dc.creatorMarinho, Francely A. G. C.-
Autor(es): dc.creatorMedeiros, Danielle S. de-
Autor(es): dc.creatorOliveira, Marcio G. G. de-
Autor(es): dc.creatorMistro, Sostenes-
Autor(es): dc.creatorMelo, Fabricio F. de-
Autor(es): dc.creatorPereira, Taiana T. S.-
Autor(es): dc.creatorGuimaraes, Ana M. S.-
Autor(es): dc.creatorTimenetsky, Jorge-
Autor(es): dc.creatorMoreira, Pablo Maciel B.-
Autor(es): dc.creatorOliveira, Sandra Helena P. de-
Autor(es): dc.creatorAlcantara, Luiz C. J.-
Autor(es): dc.creatorGiovanetti, Marta-
Autor(es): dc.creatorSantos, Luciane A.-
Autor(es): dc.creatorFonseca, Vagner-
Autor(es): dc.creatorBarreto, Fernanda K.-
Autor(es): dc.creatorCampos, Guilherme B.-
Autor(es): dc.creatorMarques, Lucas M.-
Data de aceite: dc.date.accessioned2025-08-21T22:23:14Z-
Data de disponibilização: dc.date.available2025-08-21T22:23:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/v14112424-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245781-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245781-
Descrição: dc.descriptionSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for causing Coronavirus Disease-2019 (COVID-19), a heterogeneous clinical condition that manifests varying symptom severity according to the demographic profile of the studied population. While many studies have focused on the spread of COVID-19 in large urban centers in Brazil, few have evaluated medium or small cities in the Northeast region. The aims of this study were: (i) to identify risk factors for mortality from SARS-CoV-2 infection, (ii) to evaluate the gene expression patterns of key immune response pathways using nasopharyngeal swabs of COVID-19 patients, and (iii) to identify the circulating SARS-CoV-2 variants in the residents of a medium-sized city in Northeast Brazil. A total of 783 patients infected with SARS-CoV-2 between May 2020 and August 2021 were included in this study. Clinical-epidemiological data from patients who died and those who survived were compared. Patients were also retrospectively divided into three groups based on disease severity: asymptomatic, mild, and moderate/severe. Samples were added to a qPCR array for analyses of 84 genes involved with immune response pathways and sequenced using the Oxford Nanopore MinION technology. Having pre-existing comorbidity; being male; having cardiovascular disease, diabetes, and/or chronic obstructive pulmonary disease; and PCR cycle threshold (Ct) values under 22 were identified as risk factors for mortality. Analysis of the expression profiles of inflammatory pathway genes showed that the greater the infection severity, the greater the activation of inflammatory pathways, triggering the cytokine storm and downregulating anti-inflammatory pathways. Viral genome analysis revealed the circulation of multiple lineages, such as B.1, B.1.1.28, Alpha, and Gamma, suggesting that multiple introduction events had occurred over time. This study's findings help identify the specific strains and increase our understanding of the true state of local health. In addition, our data demonstrate that epidemiological and genomic surveillance together can help formulate public health strategies to guide governmental actions.-
Descrição: dc.descriptionUniv Fed Bahia, Inst Multidisciplinary Hlth, Rua Hormindo Barros 58, BR-45029094 Vitoria Da Conquista, BA, Brazil-
Descrição: dc.descriptionMunicipal Cent Lab, Vitoria Conquista City Hall,Ave Macaubas 100, BR-45065060 Vitoria Da Conquista, BA, Brazil-
Descrição: dc.descriptionUniv Estadual Santa Cruz, Rod Jorge Amado,Km 6, BR-55662900 Ilheus, BA, Brazil-
Descrição: dc.descriptionOswaldo Cruz Inst Fiocruz, Ave Brasil 4365, BR-21040900 Rio De Janeiro, RJ, Brazil-
Descrição: dc.descriptionUniv Fed Bahia, Med Sch, Largo Terreiro Jesus S-N, BR-40026010 Salvador, BA, Brazil-
Descrição: dc.descriptionNortheast Independent Coll, Ave Luis Eduardo Magalhaes 1305, BR-45055030 Vitoria Da Conquista, BA, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Inst Biomed Sci, Ave Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP, Brazil-
Descrição: dc.descriptionVitoria Conquista City Hall,Rua Rotary Club 69, BR-45040150 Vitoria Da Conquista, BA, Brazil-
Descrição: dc.descriptionJulio de Mesquita Filho State Univ Sao Paulo, Campus Univ,Rodovia Marechal Rondon Km 527-528, BR-16015050 Aracatuba, SP, Brazil-
Descrição: dc.descriptionUniv Campus Biomed Roma, I-00128 Rome, Italy-
Descrição: dc.descriptionBahia Sch Med & Publ Heath, Av Dom Joao VI 275, BR-40290000 Salvador, BA, Brazil-
Descrição: dc.descriptionPan Amer Hlth Org, SEN Asa Norte, Lote 19 Ave Nacoes, BR-70312970 Brasilia, DF, Brazil-
Descrição: dc.descriptionJulio de Mesquita Filho State Univ Sao Paulo, Campus Univ,Rodovia Marechal Rondon Km 527-528, BR-16015050 Aracatuba, SP, Brazil-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationViruses-basel-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectgene expressions-
Palavras-chave: dc.subjectsequencing-
Palavras-chave: dc.subjectgenomic and epidemiological surveillance-
Título: dc.titleRetrospective Analysis of the SARS-CoV-2 Infection Profile in COVID-19 Positive Patients in Vitoria da Conquista, Northeast Brazil-
Tipo de arquivo: dc.typelivro digital-
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