Losartan Plays a Fungistatic and Fungicidal Activity Against Candida albicans Biofilms: Drug Repurposing for Localized Candidosis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLara, Vanessa Soares-
Autor(es): dc.creatorSilva, Rafaela Alves da-
Autor(es): dc.creatorFerrari, Tatiane Ponteado-
Autor(es): dc.creatorSantos, Carlos Ferreira dos-
Autor(es): dc.creatorOliveira, Sandra Helena Penha de-
Data de aceite: dc.date.accessioned2025-08-21T18:20:17Z-
Data de disponibilização: dc.date.available2025-08-21T18:20:17Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1089/adt.2023.013-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245642-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245642-
Descrição: dc.descriptionCandidosis is one of the most frequent opportunistic infections and exhibits variable clinical presentations, including oral localized forms. Drugs affecting the renin-angiotensin system targets inhibit secreted aspartic proteases from Candida albicans. The objective of the study was to evaluate whether losartan has antimicrobial action against C. albicans biofilms. Biofilms were treated with losartan or aliskiren (for comparison) for 24 h. Metabolic activity of viable cells and growth inhibition of C. albicans biofilms were assessed using XTT [2,3-Bis(2-Methoxy-4-Nitro-5-Sulfophenyl)-5-[(Phenyl-Amino)Carbonyl]-2H-Tetrazolium Hydroxide] and colony-forming unit assays, respectively. In addition, the cytotoxicity of the drugs on human cells was evaluated using the AlamarBlue assay. Both drugs decreased fungal viability at all concentrations. In addition, all concentrations of losartan inhibited the growth of C. albicans biofilm, ranging from 47% to 88.5%, whereas aliskiren showed inhibition from 1 to 10 mg/mL, which ranged from 16% to 97.6%. Furthermore, at certain concentrations, these drugs maintained the viability of human cells. Losartan and aliskiren have fungistatic and fungicidal action against C. albicans biofilms and are compatible with human cells. Therefore, these antihypertensive drugs can be repurposed to interfere with the metabolism and development of Candida biofilms, which are widely associated with clinical forms of candidosis, including oral localized forms such as denture stomatitis.-
Descrição: dc.descriptionUniv Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Bauru, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Integrated Res Ctr, Bauru Sch Dent, Bauru, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Immunopharmacol Lab, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Alameda Dr Otavio Pinheiro Brisolo 9-75, BR-17012901 Bauru, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Immunopharmacol Lab, Aracatuba, Brazil-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherMary Ann Liebert, Inc-
Relação: dc.relationAssay And Drug Development Technologies-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectaliskiren-
Palavras-chave: dc.subjectdenture stomatitis-
Palavras-chave: dc.subjectlosartan-
Palavras-chave: dc.subjectdrug repositioning-
Palavras-chave: dc.subjectCandida albicans-
Título: dc.titleLosartan Plays a Fungistatic and Fungicidal Activity Against Candida albicans Biofilms: Drug Repurposing for Localized Candidosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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