Circulation of HDV Genotypes in Brazil: Identification of a Putative Novel HDV-8 Subgenotype

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFiocruz MS-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMello, Francisco C. A.-
Autor(es): dc.creatorBarros, Tairine M.-
Autor(es): dc.creatorAngelice, Giovana P.-
Autor(es): dc.creatorCosta, Vanessa D.-
Autor(es): dc.creatorMello, Vinicius M.-
Autor(es): dc.creatorPardini, Maria Ines M. C.-
Autor(es): dc.creatorLampe, Elisabeth-
Autor(es): dc.creatorLago, Barbara V.-
Autor(es): dc.creatorVillar, Livia M.-
Data de aceite: dc.date.accessioned2025-08-21T18:16:54Z-
Data de disponibilização: dc.date.available2025-08-21T18:16:54Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-19-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1128/spectrum.03965-22-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/245262-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/245262-
Descrição: dc.descriptionHepatitis D virus (HDV) is classified into 8 genotypes (1 to 8) and several subgenotypes. In Brazil, HDV-3 and HDV-1 predominate; however, most of the diagnosis efforts and molecular studies are directed to the area of endemicity of the Amazon Basin. Here, we determined the molecular epidemiological profile of circulating HDV in Brazilian HBsAg-positive patients between 2013 and 2015 in areas of endemicity and non-areas of endemicity. From 38 anti-HDV-positive individuals, 13 (34.2%) had detectable HDV-RNA and 11 (28.9%) were successfully sequenced. Partial HDAg (similar to 320 nt) sequencing followed by phylogenetic analysis with reference sequences resulted in the identification of HDV-3 (9/11; 81.8%), HDV-5 (1/11; 9.1%), and HDV-8 (1/11; 9.1%). Most HDV-3 samples (8/9; 88.9%) were found in the endemic North region, while one was found in Central-West Brazil, a non-area of endemicity. HDV-5 and 8, genotypes native from African countries, were found in Sao Paulo, a cosmopolitan city from Southeast Brazil with a high circulation of immigrants. Phylogenetic analysis of HDV-8 strains indicated that the sample determined in our study, along with previously reported sequences from Brazil, formed a highly supported monophyletic clade, likely representing a putative novel HDV-8 subgenotype.-
Descrição: dc.descriptionOswaldo Cruz Institute-Oswaldo Cruz Foundation/FIOCRUZ-Brazil-
Descrição: dc.descriptionMinisterio da Saude, Fundo Nacional de Saude, Departamento de DST/AIDS e Hepatites Virais-
Descrição: dc.descriptionFiocruz MS, Inst Oswaldo Cruz, Lab Hepatites Virais, Rio De Janeiro, RJ, Brazil-
Descrição: dc.descriptionFiocruz MS, Inst Tecnol Imunobiol Bio Manguinhos, Rio De Janeiro, RJ, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista Unesp, Fac Med FMB, Div Hemocentro, Lab Biol Mol, Campus Botucatu, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista Unesp, Fac Med FMB, Div Hemocentro, Lab Biol Mol, Campus Botucatu, Botucatu, SP, Brazil-
Descrição: dc.descriptionMinisterio da Saude, Fundo Nacional de Saude, Departamento de DST/AIDS e Hepatites Virais: 25000.214350/2012-24-
Formato: dc.format8-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Soc Microbiology-
Relação: dc.relationMicrobiology Spectrum-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectHDV-
Palavras-chave: dc.subjectgenotype-
Palavras-chave: dc.subjectHDV-8 subgenotype-
Palavras-chave: dc.subjectBrazil-
Título: dc.titleCirculation of HDV Genotypes in Brazil: Identification of a Putative Novel HDV-8 Subgenotype-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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