In situ synthesis of piperine-loaded MIL-100 (Fe) in microwave for breast cancer treatment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorQuijia, Christian Rafael-
Autor(es): dc.creatorTavares Luiz, Marcela-
Autor(es): dc.creatorFernandes, Richard Perosa-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorFrem, Regina-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T18:17:28Z-
Data de disponibilização: dc.date.available2025-08-21T18:17:28Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2022.103718-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/242170-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/242170-
Descrição: dc.descriptionPiperine (PIP) is a natural alkaloid that has strong activity against breast cancer. However, due to its low solubility and bioavailability, it is unfeasible for clinical applications. Herein, we proposed an in-situ method for PIP encapsulation into the Materials of the Institut Lavoisier (MIL-100 (Fe)) using microwaves technique for fabricating novel drug delivery nanocarriers. The PIP-loaded MIL-100 (Fe) (labeled PIP@MIL-100 (Fe)) exhibited a hydrodynamic diameter of 98 ± 27.83 nm, zeta potential of +7 ± 0.6 mV, and polydispersity index of 0.03 ± 0.006. Morphological analysis of the nanosystems revealed a rhombohedral shape and particle size up to 120 nm. PIP encapsulation efficiency (EE) was found to be 95 ± 3% and PIP loading capacity was 11.02% by weight (0.12 g g−1), according to high-performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA) data, respectively. Cytotoxicity studies on breast cancer cell lines (MCF-7 and 4T1) displayed cytotoxicity (IC50) approximately three times higher than that of the free PIP within 48 h. The PIP@MIL-100(Fe) fabrication comprises a simple and cheap method for designing novel drug delivery nanosystems for further clinical assays and breast cancer treatment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Ribeirão Preto University of São Paulo (USP), Ribeirão Preto-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2018/21119–0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject4T1 cells-
Palavras-chave: dc.subjectBreast cancer treatment-
Palavras-chave: dc.subjectMCF-7 cells-
Palavras-chave: dc.subjectMetal-organic framework-based-
Palavras-chave: dc.subjectNanoparticles-
Título: dc.titleIn situ synthesis of piperine-loaded MIL-100 (Fe) in microwave for breast cancer treatment-
Tipo de arquivo: dc.typelivro digital-
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