Organ-On-A-Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects

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Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation-
Autor(es): dc.contributorGuangzhou Medical University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorKawakita, Satoru-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorMou, Lei-
Autor(es): dc.creatorMecwan, Marvin Magan-
Autor(es): dc.creatorZhu, Yangzhi-
Autor(es): dc.creatorLi, Shaopei-
Autor(es): dc.creatorSharma, Saurabh-
Autor(es): dc.creatorHernandez, Ana Lopez-
Autor(es): dc.creatorNguyen, Huu Tuan-
Autor(es): dc.creatorMaity, Surjendu-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorNakayama, Aya-
Autor(es): dc.creatorBandaru, Praveen-
Autor(es): dc.creatorAhadian, Samad-
Autor(es): dc.creatorKim, Han-Jun-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorHoller, Eggehard-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorDokmeci, Mehmet Remzi-
Autor(es): dc.creatorKhademhosseini, Ali-
Data de aceite: dc.date.accessioned2025-08-21T15:13:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:13:28Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/smll.202201401-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/242147-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/242147-
Descrição: dc.descriptionThe human brain and central nervous system (CNS) present unique challenges in drug development for neurological diseases. One major obstacle is the blood–brain barrier (BBB), which hampers the effective delivery of therapeutic molecules into the brain while protecting it from blood-born neurotoxic substances and maintaining CNS homeostasis. For BBB research, traditional in vitro models rely upon Petri dishes or Transwell systems. However, these static models lack essential microenvironmental factors such as shear stress and proper cell–cell interactions. To this end, organ-on-a-chip (OoC) technology has emerged as a new in vitro modeling approach to better recapitulate the highly dynamic in vivo human brain microenvironment so-called the neural vascular unit (NVU). Such BBB-on-a-chip models have made substantial progress over the last decade, and concurrently there has been increasing interest in modeling various neurological diseases such as Alzheimer's disease and Parkinson's disease using OoC technology. In addition, with recent advances in other scientific technologies, several new opportunities to improve the BBB-on-a-chip platform via multidisciplinary approaches are available. In this review, an overview of the NVU and OoC technology is provided, recent progress and applications of BBB-on-a-chip for personalized medicine and drug discovery are discussed, and current challenges and future directions are delineated.-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation-
Descrição: dc.descriptionDepartment of Clinical Laboratory Third Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangdong-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (Unesp), SP-
Idioma: dc.languageen-
Relação: dc.relationSmall-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectblood–brain barriers-
Palavras-chave: dc.subjectdisease modeling-
Palavras-chave: dc.subjectdrug discovery-
Palavras-chave: dc.subjectorgan-on-a-chips-
Palavras-chave: dc.subjectpersonalized medicine-
Título: dc.titleOrgan-On-A-Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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