Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.creatorCristina-Silva, Caroline-
Autor(es): dc.creatorAmaral-Silva, Lara-
Autor(es): dc.creatorSantos, Kassia Moreira-
Autor(es): dc.creatorCorrea, Gabriela Monteiro-
Autor(es): dc.creatorda Silva, Welex Candido-
Autor(es): dc.creatorFernandes, Marcia H. M. R.-
Autor(es): dc.creatorda Silva, Glauber S. F.-
Autor(es): dc.creatorGargaglioni, Luciane H.-
Autor(es): dc.creatorAlmeida, Maria C.-
Autor(es): dc.creatorBicego, Kenia C.-
Data de aceite: dc.date.accessioned2025-08-21T19:57:18Z-
Data de disponibilização: dc.date.available2025-08-21T19:57:18Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-07-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.892828-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/242099-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/242099-
Descrição: dc.descriptionTransient receptor potential vanilloid 4 (TRPV4) channels are sensitive to warm ambient temperatures (Tas), triggering heat loss responses in adult rats in a Tas range of ∼26–30°C. In birds, however, the thermoregulatory role of TRPV4 has never been shown. Here, we hypothesized that stimulation of TRPV4 induces thermolytic responses for body temperature (Tb) maintenance in birds, and that this function is already present in early life, when the Ta range for TRPV4 activation does not represent a warm condition for these animals. We first demonstrated the presence of TRPV4 in the dorsal and ventral skin of chickens (Gallus gallus domesticus) by immunohistochemistry. Then, we evaluated the effects of the TRPV4 agonist, RN1747, and the TRPV4 antagonists, HC067047 and GSK2193874, on Tb and thermoeffectors at different Tas in 5-day-old chicks and 60-day-old adult chickens. For the chicks, RN1747 transiently reduced Tb both in thermoneutrality (31°C) and in a cold Ta for this phase (26°C), which relied on huddling behavior inhibition. The TRPV4 antagonists alone did not affect Tb or thermoeffectors but blocked the Tb decrease and huddling inhibition promoted by RN1747. For the adults, TRPV4 antagonism increased Tb when animals were exposed to 28°C (suprathermoneutral condition for adults), but not to 19°C. In contrast, RN1747 decreased Tb by reducing metabolic rate and activating thermal tachypnea at 19°C, a Ta below the activation range of TRPV4. Our results indicate that peripheral TRPV4 receptors are functional in early life, but may be inhibited at that time when the range of activation (∼26–30°C) represents cold Ta for chicks, and become physiologically relevant for Tb maintenance when the activation Ta range for TRPV4 becomes suprathermoneutral for adult chickens.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Faculty of Agricultural and Veterinary Sciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Animal Science Faculty of Agricultural and Veterinary Sciences Sao Paulo State University-
Descrição: dc.descriptionInstitute of Biological Sciences Department of Physiology and Biophysics Federal University of Minas Gerais (ICB/UFMG)-
Descrição: dc.descriptionCenter for Natural and Human Sciences Federal University of ABC (UFABC)-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Faculty of Agricultural and Veterinary Sciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Animal Science Faculty of Agricultural and Veterinary Sciences Sao Paulo State University-
Descrição: dc.descriptionFAPESP: 15/04849-6 17/12627-9-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbody temperature-
Palavras-chave: dc.subjectchicken-
Palavras-chave: dc.subjecthuddling-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectperipheral thermoreceptor-
Palavras-chave: dc.subjectthermolysis-
Palavras-chave: dc.subjectthermoregulation-
Título: dc.titleCutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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