Chemogenetic inhibition of Phox2-expressing neurons in the commissural NTS decreases blood pressure in anesthetized spontaneously hypertensive rats

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Autor(es): dc.contributorUniversity of Melbourne-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMelo, Mariana Rosso-
Autor(es): dc.creatorVoger, Joshua J.-
Autor(es): dc.creatorConnelly, Angela A.-
Autor(es): dc.creatorBassi, Jaspreet K.-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorAllen, Andrew M.-
Data de aceite: dc.date.accessioned2025-08-21T15:42:49Z-
Data de disponibilização: dc.date.available2025-08-21T15:42:49Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-09-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2022.136817-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/242095-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/242095-
Descrição: dc.descriptionInterruption of the activity of neurons in the commissural portion of the nucleus of the solitary tract (cNTS) decreases blood pressure (BP) in experimental models of hypertension, such as the spontaneously hypertensive (SH) rat. To examine whether PHOX2B expressing cNTS neurons are involved in maintaining the elevated BP, we used replication-deficient viruses with a modified Phox2 binding site promoter to express the inhibitory chemogenetic allatostatin receptor or green fluorescent protein in the cNTS. Following administration of allatostatin, we observed a depressor and bradycardic response in anesthetized SH rats that expressed the allatostatin receptor. Injection of allatostatin did not affect BP or heart rate (HR) in control SH rats expressing green fluorescent protein in the cNTS. Immunohistochemistry showed that the majority of transduced cNTS neurons were PHOX2B-immunoreactive and some also expressed tyrosine hydroxylase. We conclude that in anesthetized SH rat, the Phox2B expressing cNTS neurons maintain elevated BP.-
Descrição: dc.descriptionDepartment of Anatomy and Physiology University of Melbourne-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University UNESP, SP-
Descrição: dc.descriptionFlorey Institute of Neuroscience and Mental Health University of Melbourne-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationNeuroscience Letters-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAllatostatin-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectBrainstem-
Palavras-chave: dc.subjectChemogenetics-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectNucleus of the Solitary Tract-
Título: dc.titleChemogenetic inhibition of Phox2-expressing neurons in the commissural NTS decreases blood pressure in anesthetized spontaneously hypertensive rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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