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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Hasselt University | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | Northern Illinois University | - |
Autor(es): dc.contributor | Universidad Autónoma de Baja California | - |
Autor(es): dc.contributor | Sagol School of Neuroscience | - |
Autor(es): dc.creator | Santinelli, Felipe Balistieri | - |
Autor(es): dc.creator | Sebastião, Emerson | - |
Autor(es): dc.creator | Simieli, Lucas | - |
Autor(es): dc.creator | Antunes, Barbara Moura | - |
Autor(es): dc.creator | Vieira, Luiz Henrique Palucci | - |
Autor(es): dc.creator | Kalron, Alon | - |
Autor(es): dc.creator | Barbieri, Fabio Augusto | - |
Data de aceite: dc.date.accessioned | 2025-08-21T17:11:28Z | - |
Data de disponibilização: dc.date.available | 2025-08-21T17:11:28Z | - |
Data de envio: dc.date.issued | 2023-03-02 | - |
Data de envio: dc.date.issued | 2023-03-02 | - |
Data de envio: dc.date.issued | 2022-10-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.msard.2022.104064 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/242081 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/242081 | - |
Descrição: dc.description | Background: It has been suggested that the protein Brain-derived Neurotrophic Factor (BDNF) plays a neuroprotective role in people with multiple sclerosis (pwMS). Also, BDNF seems to play a role in cognition performance. In the same line, gait in pwMS requires a higher cognitive resource, mainly during complex walking. Thus, maybe BDNF could be related to gait in pwMS. Objective: To investigate the relationship between BDNF and gait spatial-temporal parameters during unobstructed and obstructed conditions and the Timed Up and Go (TUG) in pwMS and healthy controls (HC). Methods: The study included 20 pwMS (11F/9M, 33.1±7.5 years, Expanded Disability Status Scale- EDSS 2.2±1.2) and 18 HC (13F/5M, 35.5±5.9 years). Both groups performed 20 gait attempts in two conditions: unobstructed walking (10 trials) and avoiding an obstacle. The obstacle was 15 cm in height and made of foam material. The BDNF serum concentration was collected with participants in fasting and completed before the clinical, gait, and mobility assessments. Clinical variables included the Symbol Digit Modality Test (SDMT), the Fatigue Severity Scale (FSS), and the International Physical Activity Questionnaire (IPAQ- short version). Associations between BDNF and spatial-temporal gait parameters, clinical variables, and TUG were determined by Pearson/Spearman correlations with Bonferroni's correction being applied (p<0.0013). Gait was compared by a two-way, repeated-measures ANOVA (group and condition) to characterize our cohort. Results: Reduced BDNF was observed for pwMS (41.66±4.45 ng/ml) in comparison with HC (61.67±7.07, p<0.001). However, although some correlations presented a moderate correlation between BDNF with gait variables, the correlations didn't reach a significant p-value after Bonferroni's correction. Lastly, pwMS presented shorter step length and slower step velocity for both gait conditions, with more evidence for obstacle conditions. Only pwMS changed gait behavior from unobstructed walking to obstacle avoidance conditions (i.e., reduced step length and velocity and increased step duration). Conclusion: BDNF is not related to either clinical (i.e., EDSS, SDMT, FSS, or IPAQ) or gait parameters in pwMS and HC, even in a condition involving higher cognitive demand. These results may suggest that BDNF does not play a role in these parameters' performance. | - |
Descrição: dc.description | REVAL Rehabilitation Research Center Faculty of Rehabilitation Sciences Hasselt University | - |
Descrição: dc.description | São Paulo State University (Unesp) School of Sciences Graduate Program in Movement Sciences Department of Physical Education Human Movement Research Laboratory (MOVI-LAB), SP | - |
Descrição: dc.description | Northern Illinois University Department of Kinesiology and Physical Education | - |
Descrição: dc.description | São Paulo State University (Unesp) School of Sciences Department of Physical Education Laboratory of Physiology and Sport Performance (LAFIDE), SP | - |
Descrição: dc.description | Facultad de Deportes Campus Ensenada Universidad Autónoma de Baja California | - |
Descrição: dc.description | Tel-Aviv University Department of Physical Therapy School of Health Professions Sackler Faculty of Medicine Sagol School of Neuroscience | - |
Descrição: dc.description | São Paulo State University (Unesp) School of Sciences Graduate Program in Movement Sciences Department of Physical Education Human Movement Research Laboratory (MOVI-LAB), SP | - |
Descrição: dc.description | São Paulo State University (Unesp) School of Sciences Department of Physical Education Laboratory of Physiology and Sport Performance (LAFIDE), SP | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Multiple Sclerosis and Related Disorders | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | BDNF | - |
Palavras-chave: dc.subject | Cognition | - |
Palavras-chave: dc.subject | Locomotion | - |
Palavras-chave: dc.subject | Multiple sclerosis | - |
Palavras-chave: dc.subject | Neuroprotection | - |
Título: dc.title | Is BDNF related to spatial-temporal gait parameters in people with multiple sclerosis? An observational study | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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