An Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDos Santos, Aline Martins-
Autor(es): dc.creatorJunior, Alberto Gomes Tavares-
Autor(es): dc.creatorCarvalho, Suzana Gonçalves-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T22:00:20Z-
Data de disponibilização: dc.date.available2025-08-21T22:00:20Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1381612828666220509150918-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/242051-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/242051-
Descrição: dc.description5-Fluorouracil (5-FU) is an antimetabolite drug used for over 70 years as first-line chemotherapy to treat various types of cancer, such as head, neck, breast, and colorectal cancer. 5-FU acts mainly by inhibiting thymidylate synthase, thereby interfering with deoxyribonucleic acid (DNA) replication or by 5-FU incorporat-ing into DNA, causing damage to the sequence of nucleotides. Being analogous to uracil, 5-FU enters cells using the same transport mechanism, where a is converted into active metabolites such as fluorouridine triphos-phate (FUTP), fluorodeoxyuridine monophosphate (FdUMP), and fluorodeoxyuridine triphosphate (FdUTP). Currently, there are several nano delivery systems being developed and evaluated at the preclinical level to overcome existing limitations to 5-FU chemotherapy, including liposomes, polymeric nanoparticles, polymeric micelles, nanoemulsions, mesoporous silica nanoparticles, and solid lipid nanoparticles. Therefore, it is essen-tial to choose and develop suitable analytical methods for the quantification of 5-FU and its metabolites (5-fluorouridine and 5-fluoro-2-deoxyuridine) in pharmaceutical and biological samples. Among the analytical techniques, chromatographic methods are commonly the most used for the quantification of 5-FU from different matrices. However, other analytical methods have also been developed for the determination of 5-FU, such as electrochemical methods, a sensitive, selective, and precise technique, in addition to having a reduced cost. Here, we first review the physicochemical properties, mechanism of action, and advances in 5-FU nanodelivery systems. Next, we summarize the current progress of other chromatographic methods described to determine 5-FU. Lastly, we discuss the advantages of electrochemical methods for the identification and quantification of 5-FU and its metabolites in pharmaceutical and biological samples.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 408244/2018-6-
Formato: dc.format1501-1512-
Idioma: dc.languageen-
Relação: dc.relationCurrent Pharmaceutical Design-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject5-fluorouracil-
Palavras-chave: dc.subjectAnalytical methods-
Palavras-chave: dc.subjectchromatographic-
Palavras-chave: dc.subjectelectrochemical-
Palavras-chave: dc.subjectmechanisms of action-
Palavras-chave: dc.subjectnanodrug delivery systems-
Palavras-chave: dc.subjectphysicochemical properties-
Título: dc.titleAn Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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