Transcriptome Profile Reveals Genetic and Metabolic Mechanisms Related to Essential Fatty Acid Content of Intramuscular Longissimus thoracis in Nellore Cattle

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorAgriculture & Food-
Autor(es): dc.creatorSchettini, Gustavo Pimenta-
Autor(es): dc.creatorPeripolli, Elisa-
Autor(es): dc.creatorAlexandre, Pâmela Almeida-
Autor(es): dc.creatorDos Santos, Wellington Bizarria-
Autor(es): dc.creatorPereira, Angélica Simone Cravo-
Autor(es): dc.creatorde Albuquerque, Lúcia Galvão-
Autor(es): dc.creatorBaldi, Fernando-
Autor(es): dc.creatorCuri, Rogério Abdallah-
Data de aceite: dc.date.accessioned2025-08-21T17:40:51Z-
Data de disponibilização: dc.date.available2025-08-21T17:40:51Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/metabo12050471-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241899-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241899-
Descrição: dc.descriptionBeef is a source of essential fatty acids (EFA), linoleic (LA) and alpha-linolenic (ALA) acids, which protect against inflammatory and cardiovascular diseases in humans. However, the intramuscular EFA profile in cattle is a complex and polygenic trait. Thus, this study aimed to identify potential regulatory genes of the essential fatty acid profile in Longissimus thoracis of Nellore cattle finished in feedlot. Forty-four young bulls clustered in four groups of fifteen animals with extreme values for each FA were evaluated through differentially expressed genes (DEG) analysis and two co-expression methodologies (WGCNA and PCIT). We highlight the ECHS1, IVD, ASB5, and ERLIN1 genes and the TF NFIA, indicated in both FA. Moreover, we associate the NFYA, NFYB, PPARG, FASN, and FADS2 genes with LA, and the RORA and ELOVL5 genes with ALA. Furthermore, the functional enrichment analysis points out several terms related to FA metabolism. These findings contribute to our understanding of the genetic mechanisms underlying the beef EFA profile in Nellore cattle finished in feedlot.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University, SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science University of São Paulo, SP-
Descrição: dc.descriptionCommonwealth Scientific and Industrial Research Organization Agriculture & Food-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University, SP-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University, SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: #2011/2141-0-
Descrição: dc.descriptionFAPESP: #2017/10630-2-
Descrição: dc.descriptionFAPESP: #2018/20026-8-
Idioma: dc.languageen-
Relação: dc.relationMetabolites-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBos taurus indicus-
Palavras-chave: dc.subjectDH-
Palavras-chave: dc.subjectdifferential co-expression-
Palavras-chave: dc.subjectPCIT-
Palavras-chave: dc.subjectRIF-
Palavras-chave: dc.subjectWGCNA-
Título: dc.titleTranscriptome Profile Reveals Genetic and Metabolic Mechanisms Related to Essential Fatty Acid Content of Intramuscular Longissimus thoracis in Nellore Cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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