High-throughput transcriptomics reveals the mechanisms of nanopesticides - nanoformulation, commercial formulation, active ingredient - finding safe and sustainable-by-design (SSbD) options for the environment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Aveiro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAarhus University-
Autor(es): dc.creatorGomes, Susana I. L.-
Autor(es): dc.creatorCampos, Estefânia V. R.-
Autor(es): dc.creatorFraceto, Leonardo F.-
Autor(es): dc.creatorGrillo, Renato-
Autor(es): dc.creatorScott-Fordsmand, Janeck J.-
Autor(es): dc.creatorAmorim, Mónica J. B.-
Data de aceite: dc.date.accessioned2025-08-21T22:55:55Z-
Data de disponibilização: dc.date.available2025-08-21T22:55:55Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-05-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d1en00735a-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241898-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241898-
Descrição: dc.descriptionNanoformulations are developed to offer controlled release of active ingredients (a.i.) and thus aim to keep functionality while having a smaller environmental footprint. This means that nanoformulations aim to comply with the safe and sustainable by design (SSbD) concept, as a part of (re)designing to reduce their risks. However, the toxic effects of nanoformulations, particularly to non-target organisms, are poorly known, and even more so at the mechanistic level. The aim of the present study was to investigate the possible mechanisms of toxicity of atrazine when delivered as a nanoformulation of atrazine (nano_ATZ), a commercial atrazine-based formulation (Gesaprim), and the pure a.i. (ATZ). A high-throughput gene expression microarray (4 × 44 K) was used to assess transcriptomics in Enchytraeus crypticus (non-target species). Organisms were exposed, in soil, to equitoxic reproduction effect concentrations (EC10 and EC50) for 3 and 7 days. Results showed activation of genes involved in both general and well-known mechanisms of detoxification (e.g. cytochrome P450 and GST) for all the atrazine forms. Unique effects of nano_ATZ on transcripts linked to secretion, translocation and vesicle trafficking suggested that differentiated - nano-specific - uptake and/or cellular transport might be taking place. This study on the transcriptomics of a nanoformulation, the first so far, suggested differentiated mechanisms of toxicity among the nanoformulation, the a.i. and the conventional pesticides, shedding light on the issues of safe and sustainable-by-design (SSbD) for the agrochemical industry.-
Descrição: dc.descriptionFuel Cell Technologies Program-
Descrição: dc.descriptionFundació Catalana de Trasplantament-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionFederación Española de Enfermedades Raras-
Descrição: dc.descriptionHorizon 2020-
Descrição: dc.descriptionDepartment of Biology & CESAM University of Aveiro-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Bioscience Aarhus University, Vejlsovej 25, PO BOX 314-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), SP-
Formato: dc.format2182-2194-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science: Nano-
???dc.source???: dc.sourceScopus-
Título: dc.titleHigh-throughput transcriptomics reveals the mechanisms of nanopesticides - nanoformulation, commercial formulation, active ingredient - finding safe and sustainable-by-design (SSbD) options for the environment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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