Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversity of Caxias do Sul (UCS)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBorges, Felipe Azevedo-
Autor(es): dc.creatorde Camargo Drago, Bruno-
Autor(es): dc.creatorBaggio, Luís Otávio-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorSant'Ana Pegorin Brasil, Giovana-
Autor(es): dc.creatorScontri, Mateus-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorda Silva Ribeiro, Matheus Cícero-
Autor(es): dc.creatorMilori, Débora Marcondes Bastos Pereira-
Autor(es): dc.creatorde Morais, Carla Pereira-
Autor(es): dc.creatorMarangoni, Bruno Spolon-
Autor(es): dc.creatorNicolodelli, Gustavo-
Autor(es): dc.creatorMecwan, Marvin-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorMenegatti, Carlos Renato-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Data de aceite: dc.date.accessioned2025-08-21T23:32:09Z-
Data de disponibilização: dc.date.available2025-08-21T23:32:09Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-06-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2022.05.025-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241883-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241883-
Descrição: dc.descriptionGold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV–Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biotechnology School of Sciences Humanities and Languages, SP-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd.-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionFederal University of Mato Grosso do Sul (UFMS) Institute of Physics, MS-
Descrição: dc.descriptionBrazilian Agricultural Research Corporation (EMBRAPA), SP-
Descrição: dc.descriptionFederal University of Santa Catarina (UFSC) Department of Physics Center for Physical Sciences and Mathematics (CFM), SC-
Descrição: dc.descriptionArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), RS-
Descrição: dc.descriptionSão Paulo University (USP) Engineering School of Lorena, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Biotechnology School of Sciences Humanities and Languages, SP-
Descrição: dc.descriptionFAPESP: 2011/17411-8-
Descrição: dc.descriptionFAPESP: 2012/12958-1-
Descrição: dc.descriptionFAPESP: 2014/17526-8-
Descrição: dc.descriptionFAPESP: 2017/19603-8-
Descrição: dc.descriptionFAPESP: 2020/08655-0-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Descrição: dc.descriptionCNPq: 470261/2012-9-
Formato: dc.format568-579-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGold nanoparticles-
Palavras-chave: dc.subjectLIBS-
Palavras-chave: dc.subjectSustained release-
Título: dc.titleMetronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.