Antimicrobial Photodynamic Therapy Mediated by Fotenticine and Methylene Blue on Planktonic Growth, Biofilms, and Burn Infections of Acinetobacter baumannii

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Vale of Paraiba/UNIVAP-
Autor(es): dc.creatorFigueiredo-Godoi, Lívia M. A.-
Autor(es): dc.creatorGarcia, Maíra T.-
Autor(es): dc.creatorPinto, Juliana G.-
Autor(es): dc.creatorFerreira-Strixino, Juliana-
Autor(es): dc.creatorFaustino, Eliseu Gabriel-
Autor(es): dc.creatorPedroso, Lara Luise Castro-
Autor(es): dc.creatorJunqueira, Juliana C.-
Data de aceite: dc.date.accessioned2025-08-21T21:59:34Z-
Data de disponibilização: dc.date.available2025-08-21T21:59:34Z-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2023-03-02-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics11050619-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241851-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241851-
Descrição: dc.descriptionAntimicrobial photodynamic therapy (aPDT) is considered a promising alternative strat-egy to control Acinetobacter baumannii infections. In this study, we evaluated the action of aPDT mediated by a new photosensitizer derivative from chlorin e-6 (Fotoenticine—FTC) on A. baumannii, comparing its effects with methylene blue (MB). For this, aPDT was applied on A. baumannii in planktonic growth, biofilms, and burn infections in Galleria mellonella. The absorption of FTC and MB by bacterial cells was also evaluated using microscopic and spectrophotometric analysis. The results of planktonic cultures showed that aPDT reduced the number of viable cells compared to the non-treated group for the reference and multidrug-resistant A. baumannii strains. These reduc-tions varied from 1.4 to 2 log10 CFU for FTC and from 2 log10 CFU to total inhibition for MB. In biofilms, aPDT with MB reduced 3.9 log10 CFU of A. baumannii, whereas FTC had no effect on the cell counts. In G. mellonella, only MB-mediated aPDT had antimicrobial activity on burn injuries, increasing the larvae survival by 35%. Both photosensitizers were internalized by bacterial cells, but MB showed a higher absorption compared to FTC. In conclusion, MB had greater efficacy than FTC as a photosensitizer in aPDT against A. baumannii.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Science and Technology (ICT) São Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionPhotobiology Applied to Health (Photobios) University of Vale of Paraiba/UNIVAP, São Paulo-
Descrição: dc.descriptionInstitute of Science and Technology (ICT) São Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionCNPq: 408369/2018-3-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcinetobacter baumannii-
Palavras-chave: dc.subjectburns-
Palavras-chave: dc.subjectchlorin-
Palavras-chave: dc.subjectfotoenticine-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectmethylene blue-
Palavras-chave: dc.subjectphotodynamic therapy-
Título: dc.titleAntimicrobial Photodynamic Therapy Mediated by Fotenticine and Methylene Blue on Planktonic Growth, Biofilms, and Burn Infections of Acinetobacter baumannii-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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