Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Calgary-
Autor(es): dc.contributorSão Francisco University-
Autor(es): dc.creatorLucena Périco, Larissa-
Autor(es): dc.creatorde Cássia dos Santos, Raquel-
Autor(es): dc.creatorPeixoto Rodrigues, Vinícius-
Autor(es): dc.creatorVasti Alfieri Nunes, Vânia-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorMachado da Rocha, Lúcia Regina-
Autor(es): dc.creatordos Santos, Catarina-
Autor(es): dc.creatorHiruma-Lima, Clélia Akiko-
Data de aceite: dc.date.accessioned2025-08-21T19:02:03Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:03Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10787-022-00946-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241766-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241766-
Descrição: dc.descriptionIschaemia and reperfusion (I/R)-induced gastrointestinal disorders are caused by free radicals, resulting in organ damage and functional disarrangement. This study aimed to investigate the healing effects of hydroalcoholic extracts from the leaves of Eugenia punicifolia (Kunth) DC. (HEEP) in male and female Wistar rats with I/R-induced peptic injuries, and the role of antioxidants in improving this response. After I/R-induced gastric and duodenal injuries, male and female [intact (INT) and ovariectomized (OVZ)] rats were orally treated with HEEP for 6 days. Biochemical analysis was used to determine the catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities, as well as malondialdehyde and reduced glutathione levels, to measure the gastric and duodenal healing process. Six days of HEEP treatment significantly decreased the I/R-induced gastric [male (73.68%), INT (52.83%), and OVZ (43.13%)] and duodenal damage [male (57.03%), INT (56.04%), and OVZ (54.83%)] in all groups. In OVZ rats, the healing effect of HEEP occurred because of the increased activity of SOD (2x) and CAT (1.16x) in the gastric mucosa. In the duodenal mucosa of INT rats, the extract reduced MPO (20.83%) activity. The 6-day HEEP treatment improved the healing of I/R-induced peptic ulcer injury, with the system acting differently in males and females. The antioxidant system is an important component of the HEEP activity during post-I/R mucosal recovery. This result revealed the importance of antioxidant compounds in minimizing the severity of I/R-related events.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, São Paulo-
Descrição: dc.descriptionSnyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary, 3330 Hospital Drive NW-
Descrição: dc.descriptionLaboratory of Pharmacology and Molecular Biology São Francisco University, CEP 12916-900, São Paulo-
Descrição: dc.descriptionBiosciences Institute UNESP−São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biological Science Faculty of Sciences and Languages UNESP−São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, São Paulo-
Descrição: dc.descriptionBiosciences Institute UNESP−São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biological Science Faculty of Sciences and Languages UNESP−São Paulo State University, São Paulo-
Descrição: dc.descriptionFAPESP: 2009/52237-90-
Descrição: dc.descriptionFAPESP: 2015/14979-3-
Descrição: dc.descriptionFAPESP: 2017/15610-0-
Descrição: dc.descriptionCNPq: 305570/2012-9-
Descrição: dc.descriptionCNPq: 306209/2016-0-
Descrição: dc.descriptionCAPES: 88882.183585/2018-01-
Formato: dc.format1383-1394-
Idioma: dc.languageen-
Relação: dc.relationInflammopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectEugenia punicifolia-
Palavras-chave: dc.subjectHealing effect-
Palavras-chave: dc.subjectIschaemia–reperfusion-
Palavras-chave: dc.subjectPeptic ulcers-
Título: dc.titleRole of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia-
Tipo de arquivo: dc.typelivro digital-
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