Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMojeiko, Gabriela-
Autor(es): dc.creatorApolinário, Alexsandra Conceição-
Autor(es): dc.creatorSalata, Giovanna Cassone-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorLopes, Luciana B.-
Data de aceite: dc.date.accessioned2025-08-21T23:11:52Z-
Data de disponibilização: dc.date.available2025-08-21T23:11:52Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfa.2022.128901-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241754-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241754-
Descrição: dc.descriptionWe proposed an innovative nanoemulsified system containing lamellar phases (NLP) produced by a low-energy method to enable the local-transdermal co-delivery of celecoxib and endoxifen as a potential strategy for breast cancer local chemoprevention. The NLPs were composed of surfactant:oil phase at 1:1 (w/w) and 80% water. Oleic or caprylic acid was added (2% or 5% w/w) as penetration enhancer. NLP droplet size was influenced by the type and concentration of the penetration enhancer, ranging from 290 to 450 nm with negative zeta potential. They presented pseudoplastic behavior, and after drug addition, elastic and bioadhesive properties were displayed. Compared to water (control), all formulations increased transepidermal water loss by 8.5–12.9 times, with the NLP containing 5% oleic acid promoting a more pronounced effect. No signs of vascular toxicity were observed in the HET-CAM model, suggesting safety. All NLPs increased the penetration of celecoxib and endoxifen in the skin, but the formulation containing 5% oleic acid was more effective, promoting ~ 3–22-fold increases in cutaneous delivery and ~ 11–20-fold increases in transdermal drug delivery. Combination of celecoxib and endoxifen in this NE reduced the viability of cancer cells in a synergistic manner compared to the use of isolated drugs. These results suggest the potential applicability of the NE for topical delivery and breast cancer chemoprevention.-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP) Araraquara-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP) Araraquara-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces A: Physicochemical and Engineering Aspects-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaprylic acid-
Palavras-chave: dc.subjectCelecoxib-
Palavras-chave: dc.subjectChemoprevention-
Palavras-chave: dc.subjectCo-delivery-
Palavras-chave: dc.subjectEndoxifen-
Palavras-chave: dc.subjectLocal-transdermal therapy-
Palavras-chave: dc.subjectOleic acid-
Título: dc.titleOptimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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