Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorDutra, Jessyca Aparecida Paes-
Autor(es): dc.creatorTofani, Larissa Bueno-
Autor(es): dc.creatorde Araújo, Jennifer Thayanne Cavalcante-
Autor(es): dc.creatorDi Filippo, Leonardo Delello-
Autor(es): dc.creatorMarchetti, Juliana Maldonado-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T16:58:40Z-
Data de disponibilização: dc.date.available2025-08-21T16:58:40Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics14040821-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241748-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241748-
Descrição: dc.descriptionCancer is the second most frequent cause of death worldwide, with 28.4 million new cases expected for 2040. Despite de advances in the treatment, it remains a challenge because of the tumor heterogenicity and the increase in multidrug resistance mechanisms. Thus, gene therapy has been a potential therapeutic approach owing to its ability to introduce, silence, or change the content of the human genetic code for inhibiting tumor progression, angiogenesis, and metastasis. For the proper delivery of genes to tumor cells, it requires the use of gene vectors for protecting the therapeutic gene and transporting it into cells. Among these vectors, liposomes have been the nonviral vector most used because of their low immunogenicity and low toxicity. Furthermore, this nanosystem can have its surface modified with ligands (e.g., antibodies, peptides, aptamers, folic acid, carbohy-drates, and others) that can be recognized with high specificity and affinity by receptor overex-pressed in tumor cells, increasing the selective delivery of genes to tumors. In this context, the present review address and discuss the main targeting ligands used to functionalize liposomes for im-proving gene delivery with potential application in cancer treatment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Ribeirao Preto University of Sao Paulo (USP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2020/12622-0-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectactive targeting-
Palavras-chave: dc.subjectDNA-
Palavras-chave: dc.subjectlipoplex-
Palavras-chave: dc.subjectnonviral vector-
Palavras-chave: dc.subjectnucleic acid-
Palavras-chave: dc.subjectRNA-
Título: dc.titleTargeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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