Photobiomodulation reduces inflammation but does not influence the hypoxia-inducible factor-1α in pulp tissue of rats after bleaching

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorFaculdade de Odontologia-
Autor(es): dc.creatorSilva, Isabela Joane Prado-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorChaves, Hebertt Gonzaga Dos Santos-
Autor(es): dc.creatorSivieri-Araújo, Gustavo-
Autor(es): dc.creatorBriso, André Luiz Fraga-
Autor(es): dc.creatorCosme-Silva, Leopoldo-
Autor(es): dc.creatorBenetti, Francine-
Data de aceite: dc.date.accessioned2025-08-21T17:06:32Z-
Data de disponibilização: dc.date.available2025-08-21T17:06:32Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2021-0559-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241728-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241728-
Descrição: dc.descriptionObjectives: To evaluate the influence of photobiomodulation with infrared laser (IRL) in the rat pulp tissue after bleaching, considering the immunolabeling of interleukin (IL)-23 and hypoxia-inducible factor (HIF)-1α. Methodology: The right and left molars of forty rats were divided into groups: Control – with placebo gel and Bleached – with 35% hydrogen peroxide (H2 O2). Half of the rats received one IRL application on both sides, establishing a split-mouth design, which resulted in 4 groups with 20 hemi-maxillae each: Control, Bleach, IRL, and Bleached-IRL. Rats (n=10) from each group were euthanized, at 2-and 30-days mark, and the pulp tissue was evaluated using inflammation and immunolabeling scores. Wilcoxon and Mann-Whitney statistical tests were performed (p<0.05). Results: At the 2-days mark, the Bleached group had severe inflammation and necrosis in the occlusal thirds of the pulp, and moderate to severe inflammation in cervical third, whereas the Bleached-IRL had mild to moderate inflammation (p<0.05). At the 30-days mark, there was no inflammation, but tertiary dentine formation in the bleached groups. Regarding IL-23, severe immunolabeling was observed in the Bleached group (p<0.05) at the 2-days mark; at the 30-days mark, there was a reduction in immunolabeling, in which the Bleached group had moderate and the Bleached-IRL group had mild immunolabeling (p>0.05). HIF-1α was more evident at the 2-days mark in the Bleached group, without significant difference with the Bleached-IRL (p>0.05). The difference was observed between the bleached and control groups, without immunolabeling (p<0.05); at the 30-days mark, the Bleached group had reduction in HIF-1α immunolabeling, while the Bleached-IRL had an increase; the difference remained between the bleached and the controls groups (p<0.05). Conclusion: Photobiomodulation using IRL minimized the inflammation and IL-23 immunolabeling in the pulp tissue of rats after dental bleaching, but did not influence significantly the HIF-1α immunolabeling.-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Endodontia, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionUniversidade Federal de Minas Gerais (UFMG) Faculdade de Odontologia Departamento de Odontologia Restauradora, MG-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Odontologia Restauradora, SP-
Descrição: dc.descriptionUniversidade Federal de Alagoas (UFAL) Faculdade de Odontologia, AL-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Endodontia, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Departamento de Odontologia Restauradora, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectDental bleaching-
Palavras-chave: dc.subjectHypoxia-inducible factor-1alpha-
Palavras-chave: dc.subjectInterleukin-23-
Palavras-chave: dc.subjectLow-level laser therapy-
Palavras-chave: dc.subjectPulp inflammation-
Título: dc.titlePhotobiomodulation reduces inflammation but does not influence the hypoxia-inducible factor-1α in pulp tissue of rats after bleaching-
Tipo de arquivo: dc.typelivro digital-
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