Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals

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Autor(es): dc.contributorFederal University of Maranhão - UFMA-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversity of Araraquara - UNIARA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLima, Lais R.-
Autor(es): dc.creatorConte, Gabriela V.-
Autor(es): dc.creatorBrandão, Larissa R.-
Autor(es): dc.creatorSábio, Rafael M.-
Autor(es): dc.creatorDe Menezes, Alan S.-
Autor(es): dc.creatorResende, Flávia Aparecida-
Autor(es): dc.creatorCaiut, José M. A.-
Autor(es): dc.creatorRibeiro, Sidney J. L.-
Autor(es): dc.creatorOtoni, Caio G.-
Autor(es): dc.creatorAlcântara, Ana C. S.-
Autor(es): dc.creatorBarud, Hernane Da S.-
Data de aceite: dc.date.accessioned2025-08-21T17:25:31Z-
Data de disponibilização: dc.date.available2025-08-21T17:25:31Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-04-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsapm.1c01437-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241721-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241721-
Descrição: dc.descriptionBacterial cellulose nanocrystals (BCNC) stand out as versatile biocolloidal building blocks for materials that are high-performance, owing to their inherently high crystallinity and specific modulus and surface area, and sustainable, as BCNC are both biobased and biodegradable. BCNC materials are also promising for their multifunctionality because of their huge potential to undergo physical and/or chemical surface modification. This is particularly appealing for biomedical applications thanks to the biocompatibility, high purity, and low toxicity of BCNC. We report on films based on surface-modified BCNC with varying contents of 3-glycidyloxypropyltrimethoxysilane (GPTMS) or 3-aminopropyltriethoxysilane (APTS). Importantly, these highly pure and crystalline needle-shaped BCNC were isolated from scraps generated at industrial operations when shaping bacterial cellulose membranes into wound dressings. The films were extensively characterized as far as their structural characteristics, with emphasis on the major features targeting at biological applications. Compared with pristine BCNC, the films performed better from the thermal stability standpoint and maintained the noncytotoxicity against nontransforming fibroblasts. The latter claim was independent of GPTMS content, but dose-dependent for APTS and valid for films containing up to 30% of this coupling agent. Altogether, this contribution expands the wingspan of nanocellulose-based materials in biomedical applications while mitigating the waste of natural resources by upcycling an industrial byproduct, falling within the circular bioeconomy framework.-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Maranhão - UFMA, Maranhão-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos - UFSCar, São Paulo-
Descrição: dc.descriptionBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA, São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University - UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Physics Federal University of Maranhão - UFMA, Maranhão-
Descrição: dc.descriptionMutagenisis Laboratory University of Araraquara - UNIARA, São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Philosophy Sciences and Letters at Ribeirão Preto (FFCLRP) University of São Paulo - USP, São Paulo-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Materials Engineering - DEMa Federal University of São Carlos - UFSCar, São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University - UNESP, São Paulo-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP, São Paulo-
Formato: dc.format2306-2313-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Polymer Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiocellulose-
Palavras-chave: dc.subjectcellulose nanowhiskers-
Palavras-chave: dc.subjecthybrids-
Palavras-chave: dc.subjectmicrobial cellulose-
Palavras-chave: dc.subjectsiloxanes-
Palavras-chave: dc.subjectupcycling-
Título: dc.titleFabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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