Mucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorVice Rectorrado de investigácion-
Autor(es): dc.creatorDi Filippo, Leonardo Delello-
Autor(es): dc.creatorDuarte, Jonatas-
Autor(es): dc.creatorFonseca-Santos, Bruno-
Autor(es): dc.creatorTavares Júnior, Alberto Gomes-
Autor(es): dc.creatorAraújo, Victor-
Autor(es): dc.creatorBorda, Cesar Augusto Roque-
Autor(es): dc.creatorVicente, Eduardo Festozo-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T19:43:40Z-
Data de disponibilização: dc.date.available2025-08-21T19:43:40Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/0929867328666210813154019-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241717-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241717-
Descrição: dc.descriptionThe diseases affecting the Central Nervous System (CNS) can have varied etiopathology, but they have in common silent progression, global incidence, and significant impacts on the quality of life of patients and public health systems. With the advance of biomedicine and pharmaceutical technology, new and more modern diagnostic methods and treatments were developed, repurposing the use of drugs currently available for the treatment of CNS diseases. An attractive approach is the use of alternative drug delivery platforms, such as nanocarriers, and less invasive administration routes, such as the noseto-brain, extensively explored for the delivery of drugs into the CNS. Despite many promising results, the nose-to-brain route has some physiological limitations that make it difficult to deliver drugs satisfactorily to exert therapeutic activity in the CNS. To overcome these limitations, nanostructured systems with mucoadhesive properties have stood out over the last few years in pharmaceutical R&D. In this review; we discuss how the noseto-brain route limitations can influence the delivery of drugs to the CNS and highlight the benefits that mucoadhesion can bring to these nanostructured systems. The main findings in the literature are brought together and discussed critically, focusing on how mucoadhesion can improve the biopharmaceutical properties of molecules used in the clinic, as well as their biological performance. Finally, conclusions are drawn about the points of strength of mucoadhesive nanosystems and the points that still need attention to successfully use the nose-to-brain route for the treatment of diseases that affect the CNS.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionUniversidad Catolica de Santa Maria Vice Rectorrado de investigácion-
Descrição: dc.descriptionSchool of Sciences and Engineering São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Sciences and Engineering São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 18/23416-1-
Descrição: dc.descriptionFAPESP: 2018/25707-3-
Descrição: dc.descriptionFAPESP: 2019/25125-7-
Descrição: dc.descriptionFAPESP: 2020/12622-0-
Descrição: dc.descriptionFAPESP: 2020/16573-3-
Formato: dc.format3079-3110-
Idioma: dc.languageen-
Relação: dc.relationCurrent Medicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbrain cancer-
Palavras-chave: dc.subjectbrain infection-
Palavras-chave: dc.subjectdrug delivery nanosystems-
Palavras-chave: dc.subjectmood disorders-
Palavras-chave: dc.subjectmucoadhesion-
Palavras-chave: dc.subjectNeurodegenerative diseases-
Palavras-chave: dc.subjectnose-to-brain-
Título: dc.titleMucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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