Alpha2beta1 Integrin Polymorphism in Diffuse Astrocytoma Patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorBrigham and Women’s Hospital and Harvard Medical School-
Autor(es): dc.contributorSUNY Upstate Medical University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBarretos School of Health Sciences-
Autor(es): dc.contributorMcGill University-
Autor(es): dc.creatorTeixeira, Silvia A.-
Autor(es): dc.creatorBurim, Regislaine V.-
Autor(es): dc.creatorViapiano, Mariano S.-
Autor(es): dc.creatorBidinotto, Lucas T.-
Autor(es): dc.creatorNagashi Marie, Suely K.-
Autor(es): dc.creatorFleury Malheiros, Suzana M.-
Autor(es): dc.creatorOba-Shinjo, Sueli M.-
Autor(es): dc.creatorAndrade, Augusto F.-
Autor(es): dc.creatorCarlotti, Carlos G.-
Data de aceite: dc.date.accessioned2025-08-21T19:16:03Z-
Data de disponibilização: dc.date.available2025-08-21T19:16:03Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fonc.2022.914156-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241691-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241691-
Descrição: dc.descriptionIntegrins are heterodimeric transmembrane glycoproteins resulting from the non-covalent association of an α and β chain. The major integrin receptor for collagen/laminin, α2β1 is expressed on a wide variety of cell types and plays an essential role in the adhesion of normal and tumor cells to the extracellular matrix. Integrin-triggered signaling pathways promote the invasion and survival of glioma cells by modifying the brain microenvironment. In this study, we investigated the association of a specific genetic polymorphism of integrin α2β1 with the incidence of diffusely infiltrating astrocytoma and the progression of these tumors. Single-nucleotide polymorphism in intron 7 of the integrin ITGA2 gene was examined in 158 patients and 162 controls using polymerase chain reaction and restriction enzyme analysis. The ITGA2 genotype +/+ (with a BglII restriction site in both alleles) exhibited higher frequency in grade II astrocytoma compared to control (P = 0.02) whereas the genotype -/- (lacking the BglII site) correlated with the poorest survival rate (P = 0.04). In addition, in silico analyses of ITGA2 expression from low-grade gliomas (LGG, n = 515) and glioblastomas (GBM, n = 159) indicated that the higher expression of ITGA2 in LGG was associated with poor overall survival (P < 0.0001). However, the distribution of integrin ITGA2 BglII genotypes (+/+, +/-, -/-) was not significantly different between astrocytoma subgroups III and IV (P = 0.65, 0.24 and 0.33; 0.29, 0.48, 0.25, respectively) compared to control. These results suggest a narrow association between the presence of this SNP and indicate that further studies with larger samples are warranted to analyze the relation between tumor grade and overall survival, highlighting the importance of determining these polymorphisms for prognosis of astrocytomas.-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital, São Paulo-
Descrição: dc.descriptionDepartment of Clinical Toxicological and Bromatological Analysis University of São Paulo Faculty of Pharmaceutical Sciences of Ribeirão Preto-
Descrição: dc.descriptionDepartment of Neurosurgery Brigham and Women’s Hospital and Harvard Medical School-
Descrição: dc.descriptionDepartment of Neuroscience and Physiology SUNY Upstate Medical University-
Descrição: dc.descriptionDepartment of Pathology School of Medicine UNESP- Univ. Estadual Paulista-
Descrição: dc.descriptionBarretos School of Health Sciences, Dr. Paulo Prata - FACISB-
Descrição: dc.descriptionDepartment of Neurology Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Neurology Faculty of Medicine Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Faculty of Medicine University of São Paulo-
Descrição: dc.descriptionDepartment of Human Genetics McGill University-
Descrição: dc.descriptionDepartment of Pathology School of Medicine UNESP- Univ. Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbrain microenvironment-
Palavras-chave: dc.subjectextracellular matrix-
Palavras-chave: dc.subjectinvasion-
Palavras-chave: dc.subjectITGA2-
Palavras-chave: dc.subjectlow grade glioma-
Palavras-chave: dc.subjectsingle nucleotide polymorphism-
Palavras-chave: dc.subjecttumor progression-
Título: dc.titleAlpha2beta1 Integrin Polymorphism in Diffuse Astrocytoma Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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