Regulation of VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer

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Autor(es): dc.contributorFaculty of Medicine of Sao Jose do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCuzziol, Caroline Izak-
Autor(es): dc.creatorMarzochi, Ludimila Leite-
Autor(es): dc.creatorPossebon, Vitória Scavacini-
Autor(es): dc.creatorKawasaki-Oyama, Rosa Sayoko-
Autor(es): dc.creatorMattos, Marlon Fraga-
Autor(es): dc.creatorJunior, Vilson Serafim-
Autor(es): dc.creatorFerreira, Letícia Antunes Muniz-
Autor(es): dc.creatorPavarino, Érika Cristina-
Autor(es): dc.creatorCastanhole-Nunes, Márcia Maria Urbanin-
Autor(es): dc.creatorGoloni-Bertollo, Eny Maria-
Data de aceite: dc.date.accessioned2025-08-21T20:03:27Z-
Data de disponibilização: dc.date.available2025-08-21T20:03:27Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms23137483-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241676-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241676-
Descrição: dc.descriptionMutations and alterations in the expression of VEGFA, KRAS, and NFE2L2 oncogenes play a key role in cancer initiation and progression. These genes are enrolled not only in cell proliferation control, but also in angiogenesis, drug resistance, metastasis, and survival of tumor cells. MicroRNAs (miRNAs) are small, non-coding regulatory RNA molecules that can regulate post-transcriptional expression of multiple target genes. We aimed to investigate if miRNAs hsa-miR-17-5p, hsa-miR-1405p, and hsa-miR-874-3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC). FADU (pharyngeal cancer) and HN13 (oral cavity cancer) cell lines were transfected with miR-17-5p, miR-140-5p, and miR-874-3p microRNA mimics. RNA and protein expression analyses revealed that miR-17-5p, miR-140-5p and miR-874-3p overexpression led to a downregulation of VEGFA, KRAS, and NFE2L2 gene expression in both cell lines analyzed. Taken together, our results provide evidence for the establishment of new biomarkers in the diagnosis and treatment of HNC.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionResearch Unit of Genetics and Molecular Biology (UPGEM) Department of Molecular Biology Faculty of Medicine of Sao Jose do Rio Preto (FAMERP)-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Campus Sao Jose do Rio Preto-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Campus Sao Jose do Rio Preto-
Descrição: dc.descriptionFAPESP: 2015/04403-8-
Descrição: dc.descriptionFAPESP: 2018/26166-6-
Descrição: dc.descriptionFAPESP: 2020/03209-1-
Descrição: dc.descriptionCNPq: 310987/2018-0-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiogenesis-
Palavras-chave: dc.subjectmiR-140-5p-
Palavras-chave: dc.subjectmiR-17-5p-
Palavras-chave: dc.subjectmiR-874-3p-
Título: dc.titleRegulation of VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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