Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPAR-γ

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorQueen’s University-
Autor(es): dc.contributorCruzeiro do Sul University-
Autor(es): dc.creatorFerraz Carbonel, Adriana Aparecida-
Autor(es): dc.creatorda Silva, Rafael André-
Autor(es): dc.creatorde Souza Ferreira, Luiz Philipe-
Autor(es): dc.creatorVieira, Renata Ramos-
Autor(es): dc.creatorDos Santos Simões, Ricardo-
Autor(es): dc.creatorda Silva Sasso, Gisela Rodrigues-
Autor(es): dc.creatorde Jesus Simões, Manuel-
Autor(es): dc.creatorSoares Junior, José Maria-
Autor(es): dc.creatorAzevedo Lima, Patrícia Daniele-
Autor(es): dc.creatorBorges, Fernanda Teixeira-
Data de aceite: dc.date.accessioned2025-08-21T23:24:23Z-
Data de disponibilização: dc.date.available2025-08-21T23:24:23Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/nu14132567-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241668-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241668-
Descrição: dc.descriptionDiabetes associated with post-menopause is related to a worse condition of kidney dis-ease. Taking into consideration that this disorder may be regulated by estrogenic mediators, we evaluated the renal protective effect of isoflavone. We investigated the role of the PPARγ in the pathogenesis of the disease. For this study, we used diabetic female rats in a postmenopausal model through ovariectomy. The animals were treated with isoflavone or 17β-estradiol. A dosage was ad-ministered to bring on blood glycemia, and through immunohistochemistry, we evaluated the im-munoreactivity of PPARγ in the endometrium and renal tissue. We analyzed the immunoreactivity of renal injury molecule KIM-1 and the collagen and glycogen densities in the kidney. Through bioinformatics analysis, we observed PPARγ and COL1A1 gene expression under the influence of different glucose doses. In particular, we observed that isoflavone and 17β-estradiol regulate blood glycemia. Renal injury was inhibited by isoflavone, observed by a reduction in KIM-1, along with glycogen accumulation. These benefits of isoflavone may be associated with PPARγ overexpression in the kidneys and endometrium of diabetic ovariectomized rats.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionStructural and Functional Biology Graduate Program Paulista School of Medicine Federal University of São Paulo (EPM/UNIFESP), 740 Edifício Lemos Torres—2° andar, Vila Clementino, SP-
Descrição: dc.descriptionDepartment of Gynecology Paulista School of Medicine Federal University of São Paulo (EPM/UNIFESP), SP-
Descrição: dc.descriptionBiosciences Graduate Program Institute of Biosciences Letters and Exact Sciences São Paulo State University (IBILCE/UNESP), SP-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Medicine Faculty of University of São Paulo (FMUSP), SP-
Descrição: dc.descriptionQueen’s Cardiopulmonary Unit (QCPU) Queen’s University-
Descrição: dc.descriptionDepartment of Medicine Nephrology Division Paulista School of Medicine Federal University of São Paulo (EPM/UNIFESP), SP-
Descrição: dc.descriptionInterdisciplinary Graduate Program in Health Sciences Cruzeiro do Sul University, SP-
Descrição: dc.descriptionBiosciences Graduate Program Institute of Biosciences Letters and Exact Sciences São Paulo State University (IBILCE/UNESP), SP-
Descrição: dc.descriptionFAPESP: 20/13405-2-
Idioma: dc.languageen-
Relação: dc.relationNutrients-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectisoflavone-
Palavras-chave: dc.subjectkidney-
Palavras-chave: dc.subjectpostmenopausal-
Palavras-chave: dc.subjectPPARγ-
Título: dc.titleIsoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPAR-γ-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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