Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBehavioural Neurosciences Institute (INeC)-
Autor(es): dc.contributorMax Planck Institute of Psychiatry-
Autor(es): dc.contributorBoehringer Ingelheim Pharmaceuticals Gesellschaft Mit Beschränkter Haftung & Compagnie Kommanditgesellschaft-
Autor(es): dc.creatorAlmada, Rafael C.-
Autor(es): dc.creatorFalconi-Sobrinho, Luiz Luciano-
Autor(es): dc.creatorda Silva, Juliana A.-
Autor(es): dc.creatorWotjak, Carsten T.-
Autor(es): dc.creatorCoimbra, Norberto C.-
Data de aceite: dc.date.accessioned2025-08-21T23:09:12Z-
Data de disponibilização: dc.date.available2025-08-21T23:09:12Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00213-022-06127-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241666-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241666-
Descrição: dc.descriptionRationale: The endocannabinoid modulation of fear and anxiety due to the on-demand synthesis and degradation is supported by a large body of research. Although it has been proposed that anandamide (AEA) in the substantia nigra pars reticulata (SNpr) seems to be important for the organisation of innate fear-related behaviours, a role for endogenous AEA has yet to be clarified. Methods: Mice were treated with the fatty acid amide hydrolase (FAAH) selective inhibitor URB597 at different concentrations (0.01, 0.1, 1 nmol/0.1 µL) in the SNpr and confronted by rattlesnakes (Crotalus durissus terrificus). The most effective dose of URB597 (1 nmol) was also preceded by microinjections of the CB1 receptor antagonist AM251 (0.1 nmol) into the SNpr, and mice were then confronted by the venomous snake. Results: URB597 (0.1 and 1 nmol) in the SNpr decreased the expression of defensive behaviours such as defensive attention, escape, and time spent inside the burrow of mice confronted by rattlesnakes. Moreover, pretreatment of SNpr with AM251 suppressed these antiaversive effects of URB597 in this midbrain structure. Conclusion: Overall, these data clearly indicate that the panicolytic consequences of endogenous AEA enhancement in the SNpr are mediated by CB1 receptor signalling.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGerman-Israeli Foundation for Scientific Research and Development-
Descrição: dc.descriptionLaboratory of Neuroanatomy and Neuropsychobiology Department of Pharmacology Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Science Humanities and Languages São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionBehavioural Neurosciences Institute (INeC), São Paulo-
Descrição: dc.descriptionOphidiarium LNN-FMRP-USP/INeC Ribeirão Preto Medical School of the University of São Paulo, São Paulo-
Descrição: dc.descriptionNAP-USP-Neurobiology of Emotions Research Centre (NuPNE) Ribeirão Preto Medical School of the University of São Paulo, São Paulo-
Descrição: dc.descriptionLaboratory of Neuronal Plasticity Department of Stress Neurobiology and Neurogenetics Max Planck Institute of Psychiatry-
Descrição: dc.descriptionCentral Nervous System Diseases Research Boehringer Ingelheim Pharmaceuticals Gesellschaft Mit Beschränkter Haftung & Compagnie Kommanditgesellschaft-
Descrição: dc.descriptionDepartment of Biological Sciences School of Science Humanities and Languages São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2007/01174-1-
Descrição: dc.descriptionFAPESP: 2012/03798-0-
Descrição: dc.descriptionFAPESP: 2017/11855-8-
Descrição: dc.descriptionFAPESP: 2018/03898-1-
Descrição: dc.descriptionFAPESP: 2020/15050-7-
Descrição: dc.descriptionGerman-Israeli Foundation for Scientific Research and Development: I-1442-421.13/2017-
Formato: dc.format2753-2769-
Idioma: dc.languageen-
Relação: dc.relationPsychopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnandamide-
Palavras-chave: dc.subjectCrotalus durissus terrificus venomous pit viper-
Palavras-chave: dc.subjectPanic attacks-
Palavras-chave: dc.subjectPrey vs. venomous snake paradigm-
Palavras-chave: dc.subjectSubstantia nigra pars reticulata (SNpr)-
Palavras-chave: dc.subjectURB597-
Título: dc.titleAugmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers-
Tipo de arquivo: dc.typelivro digital-
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