Enzymeless glucose sensor based on disposable Ecoflex®/graphite thermoplastic composite substrate modified with Au@GQDs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorde Lima, Lucas F.-
Autor(es): dc.creatorde Freitas, Amanda de S.M.-
Autor(es): dc.creatorFerreira, André L.-
Autor(es): dc.creatorMaciel, Cristiane Carla-
Autor(es): dc.creatorFerreira, Marystela-
Autor(es): dc.creatorde Araujo, William R.-
Data de aceite: dc.date.accessioned2025-08-21T21:43:45Z-
Data de disponibilização: dc.date.available2025-08-21T21:43:45Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.snr.2022.100102-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241651-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241651-
Descrição: dc.descriptionThere is an increasing demand for robust, affordable, and sensitive analytical devices for clinical diagnostics. Herein, we describe a simple route to produce biodegradable and disposable thermoplastic composite electrodes using the commercial polymer (Ecoflex®) and graphite microparticles. The surface of the carbon composite electrode was modified with gold nanoparticles conjugated with graphene quantum dots (Au@GQDs) for sensitive and non-enzymatic glucose sensing. The morphological and structural characterizations of the modified electrochemical device revealed a hydrophilic rough composite surface, with high dispersion of graphite in the polymer matrix and confirmed the successful superficial modification of the working electrode with spherical Au@GQDs nanoparticles. Cyclic voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) were used to electrochemically characterize the modified and nonmodified thermoplastic sensor, demonstrating a 4.5-fold enhancement of the electroactive area, higher heterogeneous electron transfer kinetics, and electrocatalytic properties for glucose sensing when the sensor was modified with Au@GQDs. The electrochemical determination of the glucose was carried out using an amperometric method applying -0.15 V in alkaline conditions (0.1 mol L−1 NaOH). Under optimized conditions, the proposed method presented a high sensitivity (4.85 A L mol−1) and a low limit of detection (LOD) of 9.12 µmol L−1. The Ecoflex:graphite/Au@GQDs sensor was applied for glucose sensing in synthetic saliva samples with recovery values ranging from 97.84% to 105.20%, highlighting the excellent accuracy of the proposed method. Finally, the electrode was subjected to thermal and biological degradation studies and presented disposable and eco-friendly characteristics. Based on these results, we believe that this new thermoplastic composite sensor modified with Au@GQDs can be an excellent candidate for a disposable, low-cost, and enzymeless electrochemical glucose sensor.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionAmerican Sleep Medicine Foundation-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionPortable Chemical Sensors Lab Department of Analytical Chemistry Institute of Chemistry State University of Campinas – UNICAMP, P.O. Box 6154, São Paulo-
Descrição: dc.descriptionPolymers and Biopolymers Technology Lab. (TecPBio) Institute of Science and Technology (ICT) Federal University of São Paulo (UNIFESP), SP-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter of Science and Technology for Sustainability (CCTS) Federal University of São Carlos (UFSCar), SP-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/19387-
Descrição: dc.descriptionFAPESP: 2018/04061-8-
Descrição: dc.descriptionFAPESP: 2018/08782-1-
Descrição: dc.descriptionFAPESP: 2019/02692-3-
Descrição: dc.descriptionAmerican Sleep Medicine Foundation: 88882.430936/2019-01-
Descrição: dc.descriptionCAPES: 88887.497915/2020-00-
Idioma: dc.languageen-
Relação: dc.relationSensors and Actuators Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiodegradable material-
Palavras-chave: dc.subjectEnzyme-free sensor-
Palavras-chave: dc.subjectGlucose detection-
Palavras-chave: dc.subjectLow-cost electrochemical sensor-
Palavras-chave: dc.subjectThermoplastic composite electrodes-
Título: dc.titleEnzymeless glucose sensor based on disposable Ecoflex®/graphite thermoplastic composite substrate modified with Au@GQDs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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