The dimerization of methyl vanillate improves its effect against breast cancer cells via pro-oxidant effect

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPessoa, Adriano de Souza-
Autor(es): dc.creatorTokuhara, Cintia Kazuko-
Autor(es): dc.creatorFakhoury, Vanessa Svizzero-
Autor(es): dc.creatorPagnan, Ana Lígia-
Autor(es): dc.creatorOliveira, Gabriela Silva Neubern de-
Autor(es): dc.creatorSanches, Mariana Liessa Rovis-
Autor(es): dc.creatorInacio, Kelly Karina-
Autor(es): dc.creatorCosta, Bruna Carolina-
Autor(es): dc.creatorXimenes, Valdecir Farias-
Autor(es): dc.creatorOliveira, Rodrigo Cardoso de-
Data de aceite: dc.date.accessioned2025-08-21T17:21:55Z-
Data de disponibilização: dc.date.available2025-08-21T17:21:55Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2022.109962-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/241650-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/241650-
Descrição: dc.descriptionPhenolic phytochemicals are a group of organic compounds with potent antioxidant features but can also act as powerful pro-oxidants. These characteristics are effective in reducing metastatic potential in cancer cells, and this effect has been associated with reactive oxygen species (ROS). Methyl vanillate (MV) and its dimer, methyl divanillate (DMV), are potent antioxidants. In the present study, we investigated the effects of MV and DMV on breast cancer cell lines MCF-7 and MDA-MB-231 and compared the results using the non-tumor cell line HB4a. Our results indicated that the compounds performed a pro-oxidant action, increasing the generation of ROS. DMV decreased the viability cell, showing a higher apoptotic effect and inhibition of proliferation than MV on both cell lines, with significant differences between groups (p < 0.05). Some modulation of NOX4, NOX5, and DUOX were observed, but the results did not correlate with the intracellular production of ROS. The dimer showed more effectivity and pro-oxidant effect than MV, impacting cell line MCF-7 in higher extension than MDA-MB-231. In conclusion, and corroborating with reported works, the dimerization of natural phenolic compounds was associated with improved beneficial biological effects as a potential cytotoxic agent to tumor cells.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP - São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP - São Paulo State University, São Paulo-
Descrição: dc.descriptionFAPESP: #2016/08890–3-
Descrição: dc.descriptionFAPESP: #2017/26309–9-
Descrição: dc.descriptionFAPESP: #2018/12607–0-
Idioma: dc.languageen-
Relação: dc.relationChemico-Biological Interactions-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMethyl divanillate-
Palavras-chave: dc.subjectMethyl Vanillate-
Palavras-chave: dc.subjectPro-oxidant-
Título: dc.titleThe dimerization of methyl vanillate improves its effect against breast cancer cells via pro-oxidant effect-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.